Downstream Processing

Pall’s acquisition of BioSMB from Tarpon Biosystems expands its downstream continuous processing offerings.

Making the switch from batch to continuous manufacturing requires a thorough understanding of the process.

Large-scale implementation of Protein A chromatography offers several challenges.

Recent technological advances in the way biologic therapeutics are purified may bring size-exclusion chromatography back into the modern purification process.

The all-synthetic clarifying product line contains both an anion-exchange nonwoven media and a fine-particle, bioburden reduction membrane.

They may not be glamorous, but buffers play an important role in biopharma manufacturing.

Tosoh Bioscience’s CaPure-HA hydroxyapatite chromatography resin is designed for the purification of monoclonal antibodies, polyclonal antibodies, and antibody fragments, and the separation of antibody isoforms and isozymes.

An increased need for higher-capacity resins and the demand for smaller batches has made disposable chromatography a more viable option.

Challenges remain for virus removal and validation.

Pall ForteBio introduces a solution for quantifying residual host cell proteins in CHO cells.

A quality-by-design approach that defines potential viral contaminants of source materials can be used to achieve viral clearance.

Careful selection of downstream processing conditions is a must.

Industry suppliers describe new technologies to facilitate downstream processing.

Suppliers see challenges to the adoption of single-use technologies for downstream processing as opportunities.

Grace's ProVance disposable Protein A chromatography column is designed for downstream purification.

OPUS technology designed to process large single-use bioreactor harvests.

The biopharmaceutical industry is developing a new approach to controlling variability in raw materials.

Research uncovers trends and factors affecting the pre-packed disposable chromatography columns market for downstream bioprocessing.

Experts discuss the advances in single-use technology for downstream bioprocessing applications.

Experts discuss the advances in single-use technology for downstream bioprocessing applications.

UPLC System for Nano- to Microscale Separations

Researchers are using current understanding of the lyophilization process to predict performance on many levels during both process development and manufacturing.

ALpHA G Capsule Filter for Single-Use Systems

Stain-Free Chromatography Workflow