Upstream Processing

Weighing the Benefits of Fermentation for New Biotherapies

The industry revisits the pros and cons of microbial fermentation at scale for biotherapeutics.

Outlining Successful Steps for Scale-Up and BLA Filings

Successful scale-up and BLA filings for products manufactured by microbial biomanufacturing require strategic planning.

Considerations for US Fetal Bovine Serum Sourcing

Extensive work has greatly expanded the possibilities for fetal bovine serum sourcing.

Upstream Processing: Biochemicals and Raw Materials

November 02, 2022

Experts reveal how to identify the “right” biochemical, the process of sourcing biochemicals, sourcing challenges, and what industry professionals should know about the space.

Using Predictive Modeling to Optimize Bioreactor Performance

October 12, 2022

Using a predictive modeling approach can help tighten up operator control over bioprocessing, which in turn can increase bioreactor output.

Cytiva Acquires CEVEC, Boosts Cell Line Development Capabilities

October 10, 2022

Cytiva’s acquisition of CEVEC Pharmaceuticals strengthens the company’s cell line development and biomanufacturing capabilities.

Thermo Fisher Scientific Launches Large-Scale Cell Culture Harvesting Solution

October 07, 2022

Thermo Fisher’s new centrifuge technology is designed to enable efficient, sustainable cell culture harvesting.

Weighing the Benefits of Fermentation for New Biotherapies

October 02, 2022

The industry revisits the pros and cons of microbial fermentation at scale for biotherapeutics.

How Predictive Modeling Can Benefit Bioreactor Performance

September 02, 2022

A predictive modeling approach can offer tighter process control, which can optimize bioreactor output.

Outlining Successful Steps for Scale-Up and BLA Filings

August 02, 2022

Successful scale-up and BLA filings for products manufactured by microbial biomanufacturing require strategic planning.

Plant-based Expression Systems are Gaining Mainstream Advantage

July 02, 2022

Industry adoption of plant-made biologics remains slow, but plant-based technology gains an advantage by mainstream exposure.

Avantor Partners with GeminiBio on Custom Hydrated Solutions and Cell Culture Media

June 29, 2022

Under the collaboration, Avantor and GeminiBio will offer custom cGMP solutions to enhance process efficiency and accelerate speed-to-market of novel emerging therapy modalities.

MilliporeSigma Intensifies Upstream Processing with New BioContinuum Seed Train Platform Offering

June 27, 2022

MilliporeSigma’s new BioContinuum Seed Train Platform offering enables a fully closed bioprocessing environment for both fed-batch and perfusion N-production.