Downstream Processing

Purification and Separation in the Downstream Train

Emerging drug classes are giving rise to challenges in downstream processing.

Single-Use Systems in Downstream Processes

Innovations aid efficient processing.

Enhancing Resins Enhances Purification

Enhanced resins improve chromatographic purification for increasingly complex biomolecules.

Driving Efficiencies in DSP Separation and Purification

May 03, 2022

An increasingly complex development pipeline and industry considerations, such as sustainability, are leading to a greater need for more efficient separation and purification in downstream processing.

Automating Cell Harvesting for Cell Therapies

May 01, 2022

Some progress has been made, but improvements are needed when harvesting cells for cell therapies.

Intensifying Downstream Processes

April 02, 2022

The need to increase efficiency and productivity is driving adoption.

What’s New in Downstream Processing?

April 01, 2022

The past year of downstream processing has brought innovations in pH sensitive antibody purification, single-use fermentation separators, and more.

Demonstrating a Fully Continuous Bioprocess

March 03, 2022

Flexible and efficient methods are needed for biopharmaceutical manufacturing.

Considering Purification and Separation in the Downstream Train

March 01, 2022

Emerging drug classes are giving rise to challenges in downstream processing, pushing the need for strategizing efficiencies.

Enhancing Resins Addresses Purification Concerns

January 02, 2022

Enhancement of resin technology can improve the ability of chromatography to purify the growing landscape of increasingly complex biomolecules.

Managing Residual Impurities in Complex Biotherapeutics

December 02, 2021

Confounding signals pose challenges to analytical methods necessary for managing residual impurity removal in biotherapeutic manufacturing.

Analytics Advances for Optimizing Downstream Processes

November 01, 2021

Surrogate analytics are no longer sufficient, as simple inexpensive real-time analytics are urgently needed for high value products.

Process Chromatography Makes Steady Progress

September 01, 2021

Process chromatography in downstream processing has seen steady improvements over the years, but there is still room for improvement.