Demand for greater process efficiency drives technology development.

Clarifying Separation Needs

Challenge: Remove debris and impurities while maximizing yield.

Cell Harvesting Separates the Good from the Bad

Topic

Kilian Brand is lab technician downstream process development at 

Florian Capito is lab head downstream process development 

Verena Oeinck is lab technician downstream process development at 

Hendrik Flato is lab engineer downstream process development at Sanofi-Aventis Deutschland GmbH.

Marc Bisschops is director at Pall Medistad.

Martin Glenz is principal scientist at Pall GmbH.

Ralf Ehret is vice dean at Provadis School of International Management and Technology.

Articles

Continuous SEC was shown to increase productivity with the same product quality and yield.

Continuous Preparative SEC for Purification of “Difficult-to-Manufacture” Proteins–A Feasibility Study

The latest advances in downstream technologies include sterile disconnects for single-use manufacturing systems, ligand technologies for purifying RNA and for COVID-19 vaccines, and an automated perfusion system.

What’s New in Downstream Technologies 

Rentschler will handle the downstream processing to provide highly purified drug substance at its headquarters in Laupheim, Germany.

Rentschler to Partner with BioNTech for COVID-19 Vaccine Manufacturing 

Cynthia A. Challener, PhD, is a contributing editor to BioPharm International.

A balance must be achieved between debris and impurity removal and maximizing product quality and yield.

Cell Harvesting Steps Separate the Good from the Bad

As technology matures, inefficiencies and process limitations in downstream process chromatography are improved.

Technology Innovations Improve Process Chromatography Performance

New therapeutics modalities and the need for greater process efficiency are driving technology development.

Chromatographic Science Clarifies Separation Challenges

Margaret (Peggy) Marino, PhD, is senior vice-president, Program Management, at AnaptysBio.

It is critical to evaluate specific considerations, from design to application, for the benefit of downstream bioprocessing and manufacturing.

Points to Consider for Continuous Downstream Bioprocessing

Jennifer Markarian is manufacturing editor of BioPharm International.

Filling and packaging of primary containers is a crucial piece of COVID-19 vaccine production.

CDMOs Build Fill/Finish Capacity for COVID-19 Vaccines

Identifying the source, assessing the risk, and removing residual impurities requires a strategic approach.

Eliminating Residual Impurities Starts with a Strategic Plan

Tools such as manufacturing execution systems, artificial intelligence, and software innovations are useful for enhancing data integrity protection.

Downstream Processing

Clarifying Separation Needs

Cell Harvesting Separates the Good from the Bad