Downstream Processing

Single-Use Fluid Handling Systems Boost Downstream Processing

The adoption of single-use technologies helps streamline downstream bioprocessing operations.

Monitoring Downstream Processing in Real Time

Near-infrared spectroscopy demonstrates process analytical technology capabilities.

Sartorius Opens New Downstream Center of Excellence Facility in UK

April 16, 2021

Sartorius has expanded in the United Kingdom with the relocation to a new facility in Havant, Hampshire, for downstream processing equipment.

Using Anion Exchange Membrane Adsorbers to Ensure Effective Virus Clearance of Challenging Parvoviruses

April 02, 2021

A series of minute virus of mice spiking studies were performed with a monoclonal antibody product and small-scale AEX membrane adsorbers to evaluate a range of critical processing conditions.

Fluid Handling Systems are Seeing Benefit from Single-Use Technologies

April 01, 2021

The adoption of single-use technologies in fluid-handling systems helps streamline downstream bioprocessing operations.

Near Infrared Spectroscopy as a Versatile PAT Tool for Continuous Downstream Bioprocessing

March 02, 2021

The need for real-time monitoring and control has spurred the development of new analytical tools.

A Unified Approach for Scaling Bioprocess Unit Operations

February 01, 2021

A unified scale-up approach, as presented here, can be applied to any unit operation.

Meeting Fill/Finish Challenges for COVID-19 Vaccines

February 01, 2021

CDMOs address the unique challenges of liquid and lyophilized forms as well as preparing for the large capacity needed for COVID-19 vaccines.

Cytiva Advances Fiber Chromatography Technology with New Launch

January 28, 2021

The launch of HiScreen Fibro PrismA, the company’s newest product for early mAb purification process development strengthens Cytiva’s new fiber-based Protein A platform.

EASY: a Disruptive mAb Purification Process to Reduce Cost of Goods

January 02, 2021

The development of an innovative purification process simplifies downstream processing for biologics.

Updating Viral Clearance for New Biologic Modalities

December 02, 2020

Viral clearance processes and guidance must evolve along with newer biotherapeutic modalities.

Continuous Preparative SEC for Purification of “Difficult-to-Manufacture” Proteins–A Feasibility Study

November 02, 2020

Continuous SEC was shown to increase productivity with the same product quality and yield.