Downstream Processing

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Time-to-Market Pressures Are Influencing Downstream Processing Innovations

By Cynthia A. Challener

August 6th 2025

Increasing efficiency and quality through effective application of advanced technologies is becoming predominant.

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Ecolab Introduces New Bioprocessing Purification Resin at BIO 2025

By Susan Haigney

June 17th 2025

The Challenges of Downstream Operations in the World of Continuous Biomanufacturing

By Jeffery Odum

June 8th 2025

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Automation Advances for Cell Harvesting in Biomanufacturing

By Feliza Mirasol

May 6th 2025

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Advantages of Single-Use Chromatography Systems for Downstream Processing

By Cynthia A. Challener

March 8th 2025

Fouling Mechanisms of Filters in the Harvest Development of Monoclonal Antibody Therapeutics—Pt 2

The authors evaluated the potential of direct filtration for multiple biopharmaceutical candidates. This article is Part 2 of the study.

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Fouling Mechanisms of Filters During the Harvest Development of Monoclonal Antibody Therapeutics with Intensified Upstream Processes—Part 2; Image: Dr_Microbe - stock.adobe.com

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Mastering SEC Biotherapeutic Characterization and Method Development

Phenomenex

April 29th 2025

Webinar Date/Time: Tue, Jun 3, 2025 2:00 PM EDT

Particle risk mitigation in biomanufacturing

Entegris

April 25th 2025

Webinar Date/Time: Tue, May 20, 2025 2:00 PM EDT

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Overcoming Viral Clearance Challenges

Cynthia A. Challener

December 5th 2024

Many factors must be considered to overcome the challenges associated with viral clearance.

Life Sciences – Sterile Filtration: Filter Sizing for Process Optimization

Entegris

November 20th 2024

Webinar Date/Time: Thu, Dec 12, 2024 11:00 AM EST

Advancing core workflows with the Intabio ZT system

SCIEX

October 18th 2024

Webinar Date/Time: Thu, Nov 7, 2024 11:00 AM EDT

Accelerating High-Titer Expression for Complex Next-Gen Biologics

Catalent

October 2nd 2024

Webinar Date/Time: Thu, Oct 31, 2024 11:00 AM EDT

Oral Lipid-Based Formulations: Unlocking Value in Early-Stage Pharmaceutical Development

Catalent

September 27th 2024

Webinar Date/Time: Wed, Oct 16, 2024 11:00 AM EDT

Robust Oligonucleotide Molecular Weight Confirmation by LC-MS

Agilent

September 24th 2024

Webinar Date/Time: Tue, Oct 8, 2024 11:00 AM EDT

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Advances in Filtration Technology

Cynthia A. Challener

September 7th 2024

Collaboration between technology providers and biopharma manufacturers are enabling both evolutionary and novel developments.

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Automation Downstream Controls Quality

Susan Haigney

August 21st 2024

Downstream processes may be streamlined by using automation.

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Streamlining Bioprocesses with Automation

Susan Haigney

August 9th 2024

Automation technologies used in the development and manufacture of biopharmaceuticals continue to evolve, providing the potential for reduced costs and time.

Freudenberg Adds Custom Single-Use Assemblies to Biopharma Product Portfolio

Feliza Mirasol

August 5th 2024

Freudenberg Medical now offers custom single-use assemblies to expand its offerings in silicone extrusion and molding for biopharma applications.

Guide Decisions through Drug Development: Localize Critical PTMs at the Sub-Unit Level

SCIEX

July 1st 2024

Webinar Date/Time: Wed, Jul 24, 2024 12:00 PM EDT

Ecolab Life Sciences and Repligen Launch New Affinity Resin for Commercial Biologics Manufacturing

Feliza Mirasol

June 13th 2024

Ecolab Life Sciences and Repligen introduce DurA Cycle, a new affinity resin for large-scale biologics manufacturing.

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Evaluating the Use of Continuous Chromatography

Feliza Mirasol

June 8th 2024

The biopharma industry is looking at continuous chromatography for sensitive molecules.

Achieve Scalable and High Recovery in rAAV Harvest Process

Avantor, Inc.

May 30th 2024

Webinar Date/Time: Wed, Jun 19, 2024 11:00 AM EDT

USP Standards to Support the Characterization of mAbs: Applications and General Chapter 129

USP

May 16th 2024

Webinar Date/Time: Thu, Jun 13, 2024 11:00 AM EDT

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HIC Demonstrates Promising Separation of Deaminated and Non-Deaminated AAV Capsids (ASGCT 2024)

Feliza Mirasol

May 10th 2024

Studies conducted by a team at Oxford Biomedica demonstrated that HIC can be used to effectively separate non-deamidated capsids from deamidated capsids.

Additives Play a Role in Removal of Empty and Partial AAV Capsids (ASGCT 2024)

Feliza Mirasol

May 8th 2024

Experiments conducted by the downstream technology team at Spark Therapeutics involving metal ion-containing additives showed improved capsid clearance in AAV production.