Articles

Navigating Obstacles and Creating Opportunities for Orphan Biologics

Managing Growth During COVID: A Supply-Chain Perspective

With the ever-growing demand for vaccines and advanced therapy products, cell culture platforms are challenged to provide cost-effective, high-yield production that can easily transition from process development through large-scale manufacturing. Ann Rossi Bilodeau, Ph.D. from Corning Life Sciences discusses what the Corning® CellCube® has to offer for the end user.

Achieving High Yield, Versatility, and Scalability for Adherent Cell Culture with Circulation/Perfusion Systems

This Application Note presents streamlined workflows for preparation of InstantPC and 2-AB labeled N-glycans coupled with analysis using Agilent LC/FLD/MS.     

Streamlined Workflows for N-Glycan Analysis of Biotherapeutics Using Agilent AdvanceBio Gly-X InstantPC and 2-AB Express Sample Preparation with LC/FLD/MS (Sept 2022)

Resources and Tools to Accelerate Oligonucleotide Therapeutics to Market

Using a pre-packed column platform enables seamless scale-up for downstream process purification. We demonstrate that neither the capacity of the packed resin nor the separation efficiency is affected when increasing the column volume.


Seamless scale-up of downstream processes (Sept 2022)

The combination of the PentaMice® platform and single B cell screening with the Beacon® system increases speed to market for monoclonal antibody antibody therapeutics. 

Antibody-based drug discovery at the speed of light

Watson Marlow Fluid Technologies Solutions (WMFTS), fluid path solutions provider of peristaltic pumps and single-use component, outlines the results of a study which makes comparisons between the semi volatiles extractables profile of post-cured and non post-cured samples of its Pumpsil platinum-cured silicone tubing.

Post-curing on the reduction of cyclosiloxanes (Sept 2022)

This application note explores the feasibility of utilizing the scale-X carbo bioreactor as a solution for seed train intensification.

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