Articles

Implementing a few recommended guidelines increases visibility in your distribution lane, incorporates robust materials, and qualifies them against relevant metrics to ensure consistent product quality in the cold chain.

Frozen Distribution of Single-Use Bags for Bioprocessing

The Sartorius-developed software, the Extractables Simulator, allows flexible combination of multiple component extractables data and prediction to facilitate the use of single-use systems in critical processing operations.

ExSim: Simplifying E&L Through in-Silico Modeling

Innovative Solutions for High-Throughput DNA Extraction from Saliva for Genomic Applications

Use an HRAM LC-MS approach to cell culture media metabolite profiling to develop a targeted quantitative assay that monitors and quantifies multiple classes of cell culture media metabolites simultaneously in a single LC-MS run.  Demonstrate that the developed quantitative assay can be used to support upstream processing optimization and quality control with excellent quantitative performance, high throughput and robustness. 

Cell Culture Media Metabolite Profiling 

Partnerships for Outsourcing 2021 

This whitepaper discusses the potential implications on media management when implementing process intensification and explores strategies for overcoming this in both new and existing facilities.

Intensifying Upstream Processing: Implications for Media Management

To maintain high purity with an untagged protein, consider protein purification workflow development using the Bio Rad NGC Chromatography System, prepacked EconoFit Columns, and Stain Free gel technology. 

Using NGC System and Stain-Free Gel Technology  

Read a case study about resin screening, process development, and scale-up purification of a retrovirus-like particle which was scalable, fast, and low-cost during the clinical-grade manufacture of retrovirus vectors.   

Process Purification Development of Retrovirus-like Particle 

A new approach using the novel, easy-to-connect Thermo Scientific MAbPac RP capillary column for determining glycosylation site occupancy of therapeutic antibodies from the analysis of their tryptic digest.

Use of a MAbPac RP capillary column to monitor glycosylation site occupancy in therapeutics

Harnessing utilization data to drive asset lifecycle decision-making

All Whitepapers