Manufacturing, Separation and Purification

Purification of Protein by HIC: Mechanistic Modeling for Improved Understanding and Process Optimization

April 02, 2023

In this article, a simple chromatographic model is proposed that is capable of predicting the impact of pH and ionic strength on HIC chromatograms.

Downstream Technologies Continue to Transform the Industry

March 30, 2023

Downstream processing will continue to see shifts with the incorporation of modern, efficient technologies.

PurePep EasyClean Services Set to Accelerate Development and Manufacturing of Peptide-based Drugs

March 22, 2023

The services are based on the company’s PurePrep EasyClean (PEC) orthogonal peptide purification technology.

Sartorius and Teknova Team Up for Gene Therapy Process Development

March 21, 2023

Sartorius BIA Separations and Teknova will collaborate to combine their technologies in an effort to streamline the downstream purification process.

Purification of Antibodies Using Novel Convecdiff Membranes Part 2: Robust Performance at Comparable Product Quality

February 02, 2023

In part 2 of this article, results from the testing of a next generation convecdiff membrane are discussed.

Purification of Antibodies Using Novel Convecdiff Membranes Part 1: Providing High Binding Capacity at Short Residence Time and Low Pressure Drops

January 02, 2023

The testing of new convecdiff membranes shows this material to be well suited for lab- and commercial-scale bind-and-elute applications.

Viral Clearance Studies: Challenges and Beyond

December 02, 2022

The design of viral clearance studies must keep pace with the quickly evolving biologic drugs industry.

Advancing Process Chromatography in DSP

June 01, 2022

Thanks to technological advances, process chromatography challenges are surmountable, but increasingly complex therapies in the pipeline will demand more efficient processes in the future.

Driving Efficiencies in DSP Separation and Purification

May 03, 2022

An increasingly complex development pipeline and industry considerations, such as sustainability, are leading to a greater need for more efficient separation and purification in downstream processing.

What’s New in Downstream Processing?

April 01, 2022

The past year of downstream processing has brought innovations in pH sensitive antibody purification, single-use fermentation separators, and more.