Downstream Processing

Kilian Brand is lab technician downstream process development at 

Florian Capito is lab head downstream process development 

Verena Oeinck is lab technician downstream process development at 

Hendrik Flato is lab engineer downstream process development at Sanofi-Aventis Deutschland GmbH.

Marc Bisschops is director at Pall Medistad.

Martin Glenz is principal scientist at Pall GmbH.

Ralf Ehret is vice dean at Provadis School of International Management and Technology.

Articles

Continuous SEC was shown to increase productivity with the same product quality and yield.

Continuous Preparative SEC for Purification of “Difficult-to-Manufacture” Proteins–A Feasibility Study

The 6th-generation Eclipse FFF system handles analytes such as proteins, polymers, viruses, gene vectors, and liposomal drug nanoparticles. 



Wyatt Technology Launches a New Line of Separation Instrumentation and Software for Analytes

Cynthia A. Challener, PhD, is a contributing editor to BioPharm International.

A balance must be achieved between debris and impurity removal and maximizing product quality and yield.

Cell Harvesting Steps Separate the Good from the Bad

As technology matures, inefficiencies and process limitations in downstream process chromatography are improved.

Technology Innovations Improve Process Chromatography Performance

New therapeutics modalities and the need for greater process efficiency are driving technology development.

Chromatographic Science Clarifies Separation Challenges

Developers need to transcend the limits of existing separation technologies, to maximize vector recovery while preserving therapeutic potency.

Challenges in Vector Purification for Gene Therapy

The authors of this study demonstrate an innovative method that is useful and complements traditional HA assays.

Using TEM-Based Image Analysis to Validate the Presence of HA Spikes on Influenza VLPs

The companies will focus on identifying peptides applicable to the affinity chromatography process used in the purification of biopharmaceuticals. 

JSR, PeptiDream Partner on Development Program for Affinity Chromatography

The new program, Cornerstone, integrates process development expertise and novel technology to remove development bottlenecks in the manufacture of gene therapy medicinal products.

BIA Separations Launches AAV Process Development Service to Accelerate Gene Therapy Production

Jennifer Markarian is manufacturing editor of BioPharm International.

Higher cell densities are driving innovations in harvesting, including closed systems for intensified processes.

Manufacturing, Separation and Purification