Downstream Processing

Sherri Dolan is a global technology consultant for Virus Clearance at Sartorius North America.

Paul Nolan is a process scientist at Sartorius in Glasgow, Scotland.

Stephen Carey is an analyst at Sartorius in Glasgow, Scotland.

Craig Quinney is a process scientist at Sartorius in Glasgow, Scotland.

Lorna Littlejohn, lorna.littlejohn@sartorius.com, is the manager of Confidence Virus Clearance Services at Sartorius in Glasgow, Scotland.

Articles

A series of minute virus of mice spiking studies were performed with a monoclonal antibody product and small-scale AEX membrane adsorbers to evaluate a range of critical processing conditions.

Using Anion Exchange Membrane Adsorbers to Ensure Effective Virus Clearance of Challenging Parvoviruses

The launch of HiScreen Fibro PrismA, the company’s newest product for early mAb purification process development strengthens Cytiva’s new fiber-based Protein A platform.

Cytiva Advances Fiber Chromatography Technology with New Launch

Thomas Prouzeau is a purification process development scientist at Sanofi.

Jerome Pezzini, Jerome.pezzini@sanofi.com, is purification process and technology leader at Sanofi.

Benoit Mothes is purification process development group head at Sanofi.

The development of an innovative purification process simplifies downstream processing for biologics.



EASY: a Disruptive mAb Purification Process to Reduce Cost of Goods

Feliza Mirasol is the science editor for 

Establishing an automated inline dilution system can potentially ease bottlenecking delays resulting from higher upstream yields.

Using Automated Inline Dilution to Ease Bottlenecking

Viral clearance processes and guidance must evolve along with newer biotherapeutic modalities.

Updating Viral Clearance for New Biologic Modalities

Kilian Brand is lab technician downstream process development at 

Florian Capito is lab head downstream process development 

Verena Oeinck is lab technician downstream process development at 

Hendrik Flato is lab engineer downstream process development at Sanofi-Aventis Deutschland GmbH.

Marc Bisschops is director at Pall Medistad.

Martin Glenz is principal scientist at Pall GmbH.

Ralf Ehret is vice dean at Provadis School of International Management and Technology.

Continuous SEC was shown to increase productivity with the same product quality and yield.

Continuous Preparative SEC for Purification of “Difficult-to-Manufacture” Proteins–A Feasibility Study

The 6th-generation Eclipse FFF system handles analytes such as proteins, polymers, viruses, gene vectors, and liposomal drug nanoparticles. 



Wyatt Technology Launches a New Line of Separation Instrumentation and Software for Analytes

Cynthia A. Challener, PhD, is a contributing editor to BioPharm International.

A balance must be achieved between debris and impurity removal and maximizing product quality and yield.

Cell Harvesting Steps Separate the Good from the Bad

As technology matures, inefficiencies and process limitations in downstream process chromatography are improved.

Technology Innovations Improve Process Chromatography Performance

New therapeutics modalities and the need for greater process efficiency are driving technology development.

Manufacturing, Separation and Purification