Manufacturing

Cynthia A. Challener, PhD, is a contributing editor to BioPharm International.

Articles

Biopharmaceutical companies and contract manufacturers respond to changing demand dynamics for upstream bioprocessing capacity.

Maximum Output Starts with Optimized Upstream Processing

Feliza Mirasol is the science editor for 

The innovation of single-use technologies is applicable early on in the manufacturing process.

Single-Use Bags Help Maintain Aseptic Ingredient Transfer to Bioreactors

Overcoming time and cost constraints can help enable seed train intensification efforts to maximize product yield.

Jumping Seed Train Intensification Hurdles to Maximize Yield

Establishing an automated inline dilution system can potentially ease bottlenecking delays resulting from higher upstream yields.

Using Automated Inline Dilution to Ease Bottlenecking

PAT advances are enabling improved process understanding, process control, and error prevention.

Control Strategies for Perfusion Cell Culture

An innovation such as synthetic biology can develop a consistently stable starting cell line for cell therapy source material.

Synthetic Biology Offers a Solution to Cell Therapy Source Material Constraints

Melisa Carpio is a global technology consultant for Cell Culture Technologies at Sartorius North America.

Bioreactor technology advances can offer seamless manufacturing scale-up and can reduce the timeline and cost of biologics production.

Current Challenges with Cell Culture Scale-up for Biologics Production 

The APS system comes equipped with filter switching, liquid management, and cell bleed to reduce risk of human error and increase process robustness.

Cytiva Introduces the Xcellerex Automated Perfusion System

This article will explore the traditional path from the laboratory to the clinic and how the fixed-bed technology provides an alternative solution to meet commercial demands.

Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines 

Process modeling offers an opportunity to troubleshoot for and anticipate difficult aspects of a bioprocess.

Manufacturing Equipment, Upstream Processing