Stem Cell Derived Exosome Production in Stirred-Tank Bioreactors
September 15, 2022
Thursday, September 15th, 2022 at 4pm CEST | 3pm BST | 10am EDT Extra cellular vesicles and especially exosomes have recently gained favor for therapeutic medicine development due to possessing structures that can be modified to conveniently deliver payloads, such as specific proteins, genetic lipids, and genetic materials including messenger RNA (mRNA, and genomic DNA (gDNA) from their progenitor cell. Most recently, there is increasing interest in the therapeutic potential of exosomes produced by Mesenchymal Stem Cells (MSCs). Stirred-tank bioreactors offer the possibility to tightly control and monitor the production of exosomes, as well as the scalability, to produce increasing amounts. However, the cultivation of stem cells in stirred-tank bioreactors requires profound knowledge and precise control of the process.