In this white paper, we utilize FlowCam LO to obtain simultaneous Flow imaging Microscopy (FIM) and LO measurements of a single sample. The results demonstrate that LO can undersize or even completely fail to detect highly transparent particles such as ETFE and some protein aggregates that FIM easily detects. These results highlight the importance of pairing LO measurements with an orthogonal technique like FIM.
In this white paper, we demonstrate the analysis capabilities of FlowCam Nano for biotherapeutic formulation development. This study compares the results from FlowCam Nano with those from FlowCam 8100 when analyzing samples containing protein aggregates, sucrose particles, and bacteria. We also demonstrate the consistency of the particle concentration measurements with FlowCam Nano and how the instrument may also be used to determine relative particle concentrations in samples.
In our new white paper, we present detailed performance results for FlowCam's Artificial Intelligence software, VisualAI, using images of different protein aggregates including monoclonal and polyclonal antibodies and silicone oil that were obtained with multiple FlowCam 8100 instruments. We also demonstrate VisualAI’s effectiveness at measuring protein aggregate content in samples with known ratios of protein aggregates and silicone oil droplets.
To gain a better appreciation for saliva and its growing use within the diagnostics research market, we’ll take a closer look at some foundational questions about saliva’s composition, physiological function, and its underappreciated history in the medical field.
Insights from lab data – often separate from the enterprise – is increasing as AI and machine learning move into the lab. Explore this shift from data collection to data science.
The clinical value of biologics for the treatment of many disease indications has been accompanied by phenomenal sales. By 2026, the global market for biologics is projected to increase to $537 billion. However, getting a promising drug candidate can be daunting. This white paper details how to optimize formulation development and tech transfer to ensure successful biologics production.
The white paper discusses a validated FFF-MALS method in line with technical specification ISO/TS 21362 for the analysis of lipid-based nanoparticles (LNPs).
SEC-MALS and CG-MALS characterize viral glycoprotein (vGP) self-association and the absolute stoichiometry and affinity of vGP antibody interactions.
Light scattering facilitates vaccine development by enabaling the analysis of size, shape, molar mass, and other parameters derived from these properties.
Wyatt’s instruments and techniques constitute platform methods for effective product and process development, as well as quality control, of AAVs for gene therapy.
This white paper presents the characterization of protein-DNA complexes using two complementary multi-angle light scattering techniques, SEC-MALS and CG-MALS.
Multi-angle light scattering, a powerful technology for biophysical characterization of biologics and LNPs, can also serve as an effective PAT tool to monitor product attributes during DSP.
SEC-MALS quantifies biophysical attributes of mRNA, including molar mass, percent aggregates, Rg and Rh, and how they are affected by formulation and storage conditions.
This note demonstrates the use of DLS and online multi-angle light scattering with field-flow fractionation (FFF-MALS) for characterizing retrovial viral vectors.
Field-flow fractionation with multi-angle and dynamic light scattering (FFF-MALS-DLS) combines size-based separation with absolute size and structure determination.
How to achieve scalable freezing & thawing of biopharmaceuticals
Impact of ice front growth speed on scalability of freezing protein solutions
This brochure covers modular set up for scaling down to 1mL, scaling up to 300L, and the shaker function.
Watson Marlow Fluid Technologies Solutions (WMFTS), fluid path solutions provider of peristaltic pumps and single-use component, outlines the results of a study which makes comparisons between the semi volatiles extractables profile of post-cured and non post-cured samples of its Pumpsil platinum-cured silicone tubing.
Reduce endotoxins in a sample to levels below the limit of detection for a LAL assay with an anion exchange resin in a flow-through chromatography mode.
Using the BioAccord LC-MS System and an Ambr® 15, we developed an analytical method for rapid mAb glycoform confirmations and mAb purity assessments. This unique method is high throughput capable and has the potential to be a fully automated platform for mid-process intraday monitoring of CQAs.
The need for flexible solutions for potent product handling is increasing. Check out our free whitepaper to discover best practices and innovative solutions available to you
