Whitepapers

How standardized, high-performance surface consumables solve the challenge of non-specific adsorption for metal-sensitive analytes in bioseparations.

You would like to cultivate your cells in a bioreactor but are unsure how to get started? We guide you through a complete bioprocess from inoculum preparation to sample analysis.

We describe the setup of a small scale perfusion bioprocess using a DASbox® Mini Bioreactor System. The system was suitable for the prolonged cultivation of CHO and HEK293 cells.

We tested the suitability of DASbox® Mini Bioreactor System in the long-term expansion of CD4+ T cells as well as the impact of different oxygen tensions on cell proliferation.

In the biopharmaceutical industry, upstream processing for plasmid DNA production is usually optimized at small scale. We demonstrate the feasibility of using the DASbox® Mini Bioreactor System for process development.

Many CDMOs outsource their nanoparticle supply chain, but in house manufacturing of nanoparticles at CDMOs is anticipated to create new market opportunities.

Protect your data from cyber theft or ransom. Learn how modern laboratory informatics from LabVantage can help you remain alert and safe from ever evolving threats.

As more gene therapy applications make inroads into research and clinical practice, the development and safe manufacturing of the therapeutic products involved have demanded more from associated analytical technologies. One of the most widely used gene-therapy vectors is AAV, and key technologies for the characterization of AAVs include CE and LC-MS.

This application note demonstrates the successful transfer, optimization and scale-up of the Rubella vaccine manufacturing process from static flasks to scale-X™ bioreactors.

A must-read for all bioprocessing scientists: This eBook covers various scale-up dimensions for bacterial and mammalian cell cultures and provides input from our Eppendorf thought leaders on scale-up challenges.

Gain knowledge on the efficiency through digital tools explores the growing world of bioprocess digitalization with outlooks on feeding strategy automation and the future perspective of artificial intelligence and machine learning in bioprocessing.

Our eBook provides insight into cell line, media, inoculation, and bioreactor options for cell-based vaccine production, as well as tips on handling viral samples.

This eBook offers consultancy on increasing reproducibility in cell culture bioprocessing and, more specifically, on pH sensor handling and calibration.

With the ever-growing demand for vaccines and advanced therapy products, cell culture platforms are challenged to provide cost-effective, high-yield production that can easily transition from process development through large-scale manufacturing. Ann Rossi Bilodeau, Ph.D. from Corning Life Sciences discusses what the Corning® CellCube® has to offer for the end user.

This Application Note presents streamlined workflows for preparation of InstantPC and 2-AB labeled N-glycans coupled with analysis using Agilent LC/FLD/MS.

Using a pre-packed column platform enables seamless scale-up for downstream process purification. We demonstrate that neither the capacity of the packed resin nor the separation efficiency is affected when increasing the column volume.

The combination of the PentaMice® platform and single B cell screening with the Beacon® system increases speed to market for monoclonal antibody antibody therapeutics.

Watson Marlow Fluid Technologies Solutions (WMFTS), fluid path solutions provider of peristaltic pumps and single-use component, outlines the results of a study which makes comparisons between the semi volatiles extractables profile of post-cured and non post-cured samples of its Pumpsil platinum-cured silicone tubing.

This application note explores the feasibility of utilizing the scale-X carbo bioreactor as a solution for seed train intensification.

Field-flow fractionation with multi-angle and dynamic light scattering (FFF-MALS-DLS) combines size-based separation with absolute size and structure determination.

SEC-MALS characterizes PEGylated proteins to determine the protein-PEG ratio and the molar masses of the constituent protein and PEG at each eluting fraction.