Eppendorf

This application note presents a protocol for Sf9 insect cell culture in stirred-tank bioreactors and recombinant protein production via a baculovirus vector system.

Cell and gene therapies offer new opportunities for the development of potentially life-saving treatments for previously incurable diseases. This eBook informs on bioprocess solutions to support novel drug development.

A must-read for all bioprocessing scientists: This eBook covers various scale-up dimensions for bacterial and mammalian cell cultures and provides input from our Eppendorf thought leaders on scale-up challenges.

Gain knowledge on the efficiency through digital tools explores the growing world of bioprocess digitalization with outlooks on feeding strategy automation and the future perspective of artificial intelligence and machine learning in bioprocessing.

Our eBook provides insight into cell line, media, inoculation, and bioreactor options for cell-based vaccine production, as well as tips on handling viral samples.

This eBook offers consultancy on increasing reproducibility in cell culture bioprocessing and, more specifically, on pH sensor handling and calibration.

Thursday, September 15th, 2022 at 4pm CEST | 3pm BST | 10am EDT Extra cellular vesicles and especially exosomes have recently gained favor for therapeutic medicine development due to possessing structures that can be modified to conveniently deliver payloads, such as specific proteins, genetic lipids, and genetic materials including messenger RNA (mRNA, and genomic DNA (gDNA) from their progenitor cell. Most recently, there is increasing interest in the therapeutic potential of exosomes produced by Mesenchymal Stem Cells (MSCs). Stirred-tank bioreactors offer the possibility to tightly control and monitor the production of exosomes, as well as the scalability, to produce increasing amounts. However, the cultivation of stem cells in stirred-tank bioreactors requires profound knowledge and precise control of the process.

In this interview we will discuss recent strategies for upstream bioprocess analytics and how a thorough process understanding can improve product quality and process efficiency.