Tosoh Bioscience

Articles

Multi-Column Chromatography for mAb Capture and Viral Clearance

Traditionally, producing biotherapeutics such as monoclonal antibodies required a multi-step process to remove impurities, including host-cell proteins, DNA, adventitious viruses, and antibody aggregates. However, by converting the process from batch chromatography to multi-column chromatography (MCC), there is potential to reduce costs and shorten production times for the capture and purification of high-quality mAbs.

Economic Impact of Multi-Column Chromatography for Protein A

Transitioning to intensified, continuous chromatography can increase efficiencies and decrease time and cost when analyzing protein A.

Two-step mAb Purification Using Multi-column Chromatography (Nov 2023)

A two-step mAb purification process was developed, tested, and intensified. Increased process productivity, while exhibiting robust impurity clearance and high yield, was achieved.

Multi-Column Chromatography (MCC) in Biomanufacturing, Now and in the Future (October 2023)

Intensified continuous chromatography, a type of Multi-Column Chromatography (MCC), has emerged as a valuable technique in downstream bioprocessing that enables increases in productivity. In this podcast, MCC Product Specialist, Jennifer Knister, will discuss how adopting MCC can reduce costs, decrease suite time, and lead to higher resin utilization, along with why these benefits are particularly worthwhile in multi-product facilities.

Multi-Column Chromatography (MCC) in Biomanufacturing, Now and in the Future

Intensified continuous chromatography, a type of Multi-Column Chromatography (MCC), has emerged as a valuable technique in downstream bioprocessing that enables increases in productivity. In this podcast, MCC Product Specialist, Jennifer Knister, will discuss how adopting MCC can reduce costs, decrease suite time, and lead to higher resin utilization, along with why these benefits are particularly worthwhile in multi-product facilities.

Two-step mAb Purification Using Multi-column Chromatography

A two-step mAb purification process was developed, tested, and intensified. Increased process productivity, while exhibiting robust impurity clearance and high yield, was achieved.

Benefits of Using Continuous Chromatography for mAb Purification

While continuous bioprocessing has been around for decades, it is becoming more attractive as technological advances and new trends in the biopharma industry emerge.