Tosoh Bioscience

Articles

Two-step mAb Purification Using Multi-column Chromatography (Nov 2023)

A two-step mAb purification process was developed, tested, and intensified. Increased process productivity, while exhibiting robust impurity clearance and high yield, was achieved.

Multi-Column Chromatography (MCC) in Biomanufacturing, Now and in the Future (October 2023)

Intensified continuous chromatography, a type of Multi-Column Chromatography (MCC), has emerged as a valuable technique in downstream bioprocessing that enables increases in productivity. In this podcast, MCC Product Specialist, Jennifer Knister, will discuss how adopting MCC can reduce costs, decrease suite time, and lead to higher resin utilization, along with why these benefits are particularly worthwhile in multi-product facilities.

Multi-Column Chromatography (MCC) in Biomanufacturing, Now and in the Future

Intensified continuous chromatography, a type of Multi-Column Chromatography (MCC), has emerged as a valuable technique in downstream bioprocessing that enables increases in productivity. In this podcast, MCC Product Specialist, Jennifer Knister, will discuss how adopting MCC can reduce costs, decrease suite time, and lead to higher resin utilization, along with why these benefits are particularly worthwhile in multi-product facilities.

Two-step mAb Purification Using Multi-column Chromatography

A two-step mAb purification process was developed, tested, and intensified. Increased process productivity, while exhibiting robust impurity clearance and high yield, was achieved.

Benefits of Using Continuous Chromatography for mAb Purification

While continuous bioprocessing has been around for decades, it is becoming more attractive as technological advances and new trends in the biopharma industry emerge.

Continuous Multi-Column Protein L Purification of Fab-Fragments

Transferring from a conventional batch mode to a multi-column chromatography (MCC) process significantly increases the productivity of the Fab fragment capture.

Development and scale-up of an antibody platform

A 2-step platform to purify Pertuzumab is developed, using 1 mL and 5 mL pre-packed columns. Then, scale-up is demonstrated using 50 and 200 mL pre-packed columns.

Process Design of a Two-Step mAb Purification Using a Multi-Column Continuous Chromatography Platform

Wednesday, October 26th, 2022 Session 1: 9am EDT|6am PDT|2pm BST|3pm CEST Session 2: 2pm EDT|11am PDT|7pm BST|8pm CEST Design and intensify a multi-step mAb purification process with limited investment. Lower the complexity barrier to multi-column continuous chromatography.