Direct LC-MS Characterization of Glycoform Distribution and Low Molecular Weight Impurities in mAb Process

Using the BioAccord LC-MS System and an Ambr® 15, we developed an analytical method for rapid mAb glycoform confirmations and mAb purity assessments. This unique method is high throughput capable and has the potential to be a fully automated platform for mid-process intraday monitoring of CQAs.