Whitepapers

We tested the suitability of DASbox® Mini Bioreactor System in the long-term expansion of CD4+ T cells as well as the impact of different oxygen tensions on cell proliferation.

In the biopharmaceutical industry, upstream processing for plasmid DNA production is usually optimized at small scale. We demonstrate the feasibility of using the DASbox® Mini Bioreactor System for process development.

Many CDMOs outsource their nanoparticle supply chain, but in house manufacturing of nanoparticles at CDMOs is anticipated to create new market opportunities.

Protect your data from cyber theft or ransom. Learn how modern laboratory informatics from LabVantage can help you remain alert and safe from ever evolving threats.

Speed-to-market, flexibility and process efficiency are more important than ever in biopharmaceutical production. And so is the importance of single-use systems. Single Use Support enables innovative process solutions around aseptic fluid management and improves aseptic liquid transfer in various manufacturing facilities. And yet there is hesitation.Dr. Lorenzo De Benedictis provides insights and outlook on the future of single-use systems in Biopharma.

As more gene therapy applications make inroads into research and clinical practice, the development and safe manufacturing of the therapeutic products involved have demanded more from associated analytical technologies. One of the most widely used gene-therapy vectors is AAV, and key technologies for the characterization of AAVs include CE and LC-MS.

This application note demonstrates the successful transfer, optimization and scale-up of the Rubella vaccine manufacturing process from static flasks to scale-X™ bioreactors.

Gain knowledge on the efficiency through digital tools explores the growing world of bioprocess digitalization with outlooks on feeding strategy automation and the future perspective of artificial intelligence and machine learning in bioprocessing.

Our eBook provides insight into cell line, media, inoculation, and bioreactor options for cell-based vaccine production, as well as tips on handling viral samples.

This eBook offers consultancy on increasing reproducibility in cell culture bioprocessing and, more specifically, on pH sensor handling and calibration.

With the ever-growing demand for vaccines and advanced therapy products, cell culture platforms are challenged to provide cost-effective, high-yield production that can easily transition from process development through large-scale manufacturing. Ann Rossi Bilodeau, Ph.D. from Corning Life Sciences discusses what the Corning® CellCube® has to offer for the end user.

This Application Note presents streamlined workflows for preparation of InstantPC and 2-AB labeled N-glycans coupled with analysis using Agilent LC/FLD/MS.

Using a pre-packed column platform enables seamless scale-up for downstream process purification. We demonstrate that neither the capacity of the packed resin nor the separation efficiency is affected when increasing the column volume.

The combination of the PentaMice® platform and single B cell screening with the Beacon® system increases speed to market for monoclonal antibody antibody therapeutics.

Watson Marlow Fluid Technologies Solutions (WMFTS), fluid path solutions provider of peristaltic pumps and single-use component, outlines the results of a study which makes comparisons between the semi volatiles extractables profile of post-cured and non post-cured samples of its Pumpsil platinum-cured silicone tubing.

This application note explores the feasibility of utilizing the scale-X carbo bioreactor as a solution for seed train intensification.

Field-flow fractionation with multi-angle and dynamic light scattering (FFF-MALS-DLS) combines size-based separation with absolute size and structure determination.

SEC-MALS characterizes PEGylated proteins to determine the protein-PEG ratio and the molar masses of the constituent protein and PEG at each eluting fraction.

Wyatt's instruments and techniques constitute platform methods for effective product and process development, as well as quality control, of AAVs for gene therapy.

Multi-angle light scattering is a powerful technology for the biophysical characterization of biologics and LNPs. It can also serve as an effective PAT tool to monitor product attributes during DSP.

This note demonstrates the use of DLS and online multi-angle light scattering with field-flow fractionation (FFF-MALS) for characterizing retroviral viral vectors.

SEC-MALS and CG-MALS characterize viral glycoprotein (vGP) self-association and the absolute stoichiometry and affinity of vGP: antibody interactions.