Lipid Nanoparticle and Liposome Quantification

Field-flow fractionation with multi-angle and dynamic light scattering (FFF-MALS-DLS) combines size-based separation with absolute size and structure determination.

Quantifying Protein PEGylation Processes

SEC-MALS characterizes PEGylated proteins to determine the protein-PEG ratio and the molar masses of the constituent protein and PEG at each eluting fraction.

Characterizing AAVs with Light Scattering

Wyatt's instruments and techniques constitute platform methods for effective product and process development, as well as quality control, of AAVs for gene therapy.

Real-time Product Attributes; from Lab to Plant

Multi-angle light scattering is a powerful technology for the biophysical characterization of biologics and LNPs. It can also serve as an effective PAT tool to monitor product attributes during DSP.

Characterizing Lentiviral and Gammaretroviral Vectors

This note demonstrates the use of DLS and online multi-angle light scattering with field-flow fractionation (FFF-MALS) for characterizing retroviral viral vectors.

Quantifying Antibody and Viral Glycoprotein Interactions

SEC-MALS and CG-MALS characterize viral glycoprotein (vGP) self-association and the absolute stoichiometry and affinity of vGP: antibody interactions.

LNP Characterization in Product Development

Light scattering quantifies key attributes of lipid nanoparticle gene vectors, such as payload, size, titer, and stability in formulation and physiological media.

Light Scattering Toolkit for Vaccines

Light scattering facilitates vaccine development by enabling the analysis of size, shape, molar mass, and other parameters derived from these properties.

Freeze-thaw Stability Studies by DLS

Many biologics must undergo freeze-thaw stability testing during product development. We describe a method for performing this test using a DLS plate reader.

Characterizing mRNA using SEC-MALS

SEC-MALS quantifies biophysical attributes of mRNA, including molar mass, percent aggregates, Rg and Rh, and how they are affected by formulation and storage conditions.