Wyatt

Webinar Date/Time: Thu, Sep 5, 2024 11:00 AM EDT

Webinar Date/Time: Wed, Nov 1, 2023 11:00 AM EDT

Field-flow fractionation with multi-angle and dynamic light scattering (FFF-MALS-DLS) combines size-based separation with absolute size and structure determination.

SEC-MALS characterizes PEGylated proteins to determine the protein-PEG ratio and the molar masses of the constituent protein and PEG at each eluting fraction.

Wyatt's instruments and techniques constitute platform methods for effective product and process development, as well as quality control, of AAVs for gene therapy.

Multi-angle light scattering is a powerful technology for the biophysical characterization of biologics and LNPs. It can also serve as an effective PAT tool to monitor product attributes during DSP.

This note demonstrates the use of DLS and online multi-angle light scattering with field-flow fractionation (FFF-MALS) for characterizing retroviral viral vectors.

SEC-MALS and CG-MALS characterize viral glycoprotein (vGP) self-association and the absolute stoichiometry and affinity of vGP: antibody interactions.

Light scattering quantifies key attributes of lipid nanoparticle gene vectors, such as payload, size, titer, and stability in formulation and physiological media.

Light scattering facilitates vaccine development by enabling the analysis of size, shape, molar mass, and other parameters derived from these properties.

Many biologics must undergo freeze-thaw stability testing during product development. We describe a method for performing this test using a DLS plate reader.

SEC-MALS quantifies biophysical attributes of mRNA, including molar mass, percent aggregates, Rg and Rh, and how they are affected by formulation and storage conditions.

The white paper discusses a validated FFF-MALS method in line with technical specification ISO/TS 21362 for the analysis of lipid-based nanoparticles (LNPs).

SEC-MALS and CG-MALS characterize viral glycoprotein (vGP) self-association and the absolute stoichiometry and affinity of vGP antibody interactions.

Light scattering facilitates vaccine development by enabaling the analysis of size, shape, molar mass, and other parameters derived from these properties.

Wyatt’s instruments and techniques constitute platform methods for effective product and process development, as well as quality control, of AAVs for gene therapy.

This white paper presents the characterization of protein-DNA complexes using two complementary multi-angle light scattering techniques, SEC-MALS and CG-MALS.

Multi-angle light scattering, a powerful technology for biophysical characterization of biologics and LNPs, can also serve as an effective PAT tool to monitor product attributes during DSP.

SEC-MALS quantifies biophysical attributes of mRNA, including molar mass, percent aggregates, Rg and Rh, and how they are affected by formulation and storage conditions.

This note demonstrates the use of DLS and online multi-angle light scattering with field-flow fractionation (FFF-MALS) for characterizing retrovial viral vectors.

Field-flow fractionation with multi-angle and dynamic light scattering (FFF-MALS-DLS) combines size-based separation with absolute size and structure determination.

Dynamic and static light scattering are applied to test the effect of ramp rate on thermostability measurements of an IgG. The choice of heating rate significantly impacts results.

Tuesday, August 17, 2021 at 11am EDT| 8am PDT| 4pm BST| 5pm CEST Characterizing viral proteins and their interactions is key to understanding of how a virus infects cells and for the development of protein-based drugs. Learn how light scattering technology can be used for the biophysical characterization of viral proteins, mAbs, and their interactions.

***Live: Wednesday, February 24, 2021 at 11am EST| 8am PST| 4pm GMT| 5pm CET*** Do biologics aggregate in blood or serum? *On Demand until Feb. 24, 2022*

***Live: Tuesday, November 17, 2020 at 8am PST| 11am EST| 4pm GMT| 5pm CET***Shine a light on the (co-)formulation and stability one or more proteins.***On demand available after final airing until NOV. 17, 2021***