Development of an In Situ Spectroscopic Method for Cleaning Validation using Mid-IR Fiber-Optics

May 15, 2002
Peter J. Melling

,
Samuel P. Hernandez-Rivera

,
Javier Goenaga-Polo

,
Narinder K. Mehta

,
Mary A. Thomson

,
David Hernandez

BioPharm International, BioPharm International-05-01-2002, Volume 15, Issue 5

by Narinder K. Mehta, Javier Goenaga-Polo, Samuel P. Hernandez-Rivera, David Hernandez, Peter J. Melling, and Mary A. Thomson, Remspec Corporation A fiber-optic, mid-IR spectroscopy probe combined with a grazing-angle reflectance sampling head can be used as a solvent-free in situ method for validating cleanliness with substantial improvement in accuracy.