Development of an In Situ Spectroscopic Method for Cleaning Validation using Mid-IR Fiber-Optics

Peter J. Melling;Samuel P. Hernandez-Rivera;Javier Goenaga-Polo;Narinder K. Mehta;Mary A. Thomson;David Hernandez;

Development of an In Situ Spectroscopic Method for Cleaning Validation using Mid-IR Fiber-Optics

Published on: May 15, 2002

Peter J. Melling, Samuel P. Hernandez-Rivera, Javier Goenaga-Polo, Narinder K. Mehta, Mary A. Thomson, David Hernandez

BioPharm International, BioPharm International-05-01-2002, Volume 15, Issue 5

by Narinder K. Mehta, Javier Goenaga-Polo, Samuel P. Hernandez-Rivera, David Hernandez, Peter J. Melling, and Mary A. Thomson, Remspec Corporation A fiber-optic, mid-IR spectroscopy probe combined with a grazing-angle reflectance sampling head can be used as a solvent-free in situ method for validating cleanliness with substantial improvement in accuracy.