Upstream Processing

Probiodrug has signed an agreement with Rentschler Biotechnologie GmbH for the development of PBD-C06, a pGlu-Abeta-specific monoclonal antibody, as treatment for patients with Alzheimer’s disease.

Rafe Swan/Getty Images; Dan WardIrreproducible preclinical research is a global, expensive, and well-recognized problem that contributes to delays a

Aragen Bioscience has licensed ProteoNic Biotechnology’s 2G UNic recombinant protein production technology, which increases manufacturing efficiency and reduces cost of goods for recombinant biologicals.

Biopharmaceutical company BeiGene plans to build facility in Suzhou to expand its clinical capability and prepare for commercial manufacturing.

GEA's self-contained homogenizer is designed for laboratory applications, including cell dispersions.

A thorough cell-bank testing plan is necessary to certify the safety and purity of a resulting biopharmaceutical product.

The Mobius 2000-L single-use bioreactor from EMD Millipore offers configurable software, hardware, and single-use Flexware assemblies for suspension and adherent cell-culture applications.

Catalent licenses Excelimmune’s antibody combination therapy platform toenable the manufacture of multiple recombinant antibodies in a single batch culture.

Biogen plans to build a biologics manufacturing plant in northwest Switzerland using next-generation technologies to create efficiency and sustainability.

GSK will invest in an additional downstream isolation facility for amoxicillin production in Singapore.

Australian company, Genea Biocells, will open a facility in San Diego, California for cell and culture-media manufacturing and R&D.

IDT Biologika acquired Aeras' vaccine manufacturing facility, and the companies will work together on tuberculosis vaccine development.

Novasep's new antibody drug conjugate facility at its site in Le Mans, France will be commissioned in 2016.

Contract service providers share insights on biopharma market developments and the implications of biosimilar drug approvals.

EMD Millipore debuts a new cell-culture media compacting technology that will turn messy, dry powders into granules.

Biopharma companies on both sides of the Atlantic ship more of their assay testing to outside service providers.

Medicago's new production facility will make plant-based vaccines and therapeutics.

Choosing the optimal protein expression vector depends on strain, promoter, and a number of other factors.

This article presents first-hand perspectives from industry users to suppliers of single-use sensors.

Making the switch from batch to continuous manufacturing requires a thorough understanding of the process.

It is important to understand degradation and processing to maintain product stability in biologics.

EMD Millipore will provide process development services for Precision Biologics’ preclinical monoclonal antibody.

They may not be glamorous, but buffers play an important role in biopharma manufacturing.

The use of commercially available media to achieve high titer in early process development is discussed.

Catalent announced that it would partner with Mitsubishi Gas Chemical Company, and its subsidiary MGC Pharma, to promote GPEx technology, a high-titer vector for stable mammalian cell lines.

Sanofi will tap into Boehringer Ingelheim’s therapeutic monoclonal antibody manufacturing capabilities.

Single-use components aid efficiency in automated personalized therapy manufacturing.

Improving efficiency, value chain, quality, and protein complexity with advanced bioprocess development.

Protein Sciences will evaluate sourcing Flublok from its Japanese licensee, UMN Pharma, which already runs a large-scale facility for the vaccine.