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|Articles|October 7, 2015
Probiodrug Signs Manufacturing Agreement with Rentschler for Monoclonal Antibody PBD-C06
Author(s)BioPharm International Editors
Probiodrug has signed an agreement with Rentschler Biotechnologie GmbH for the development of PBD-C06, a pGlu-Abeta-specific monoclonal antibody, as treatment for patients with Alzheimer’s disease.
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Biopharmaceutical company, Probiodrug,
The contract comprises all stages of production and processing from initial cell-line development through to the manufacturing of material for preclinical and clinical studies. Rentschler is an independent contract manufacturer with experience in producing biopharmaceuticals for more than 40 years.
PBD-C06 is a chimeric, de-immunized monoclonal antibody selected as a candidate with the best safety, efficacy, and pharmacological profile from among several pre-clinical candidates. It targets pGlu-Abeta, aiming to selectively clear the brain of pGlu-Abeta while leaving non-toxic forms of Abeta untouched. In Alzheimer’s disease animal models, PBD-C06 reduced pGlu-Abeta and total Abeta levels and positively affected memory function.
To date Probiodrug has progressed two complementary strategies for tackling pGlu-Abeta, with two medicine candidates in development-PQ912, a small molecule inhibitor of Glutaminyl Cyclase, in phase 2, and PBD-C06, a pGlu-Abeta-specific mAB in preclinical stage.
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