Whitepapers

In many laboratories, space is at a premium. Especially when centralized laboratory water systems are required to dispense pure and ultrapure water for your applications. To maximize your lab space capabilities, you shouldn’t have to adapt your water system to the laboratory. The system should adapt to your needs. In addition to being economical in terms of its footprint, flexibility in dispensing water is essential. Users need full control over quality parameters at the point of use and the ability to fill different sized containers at the same time across the lab. Sartorius will discuss an innovative and flexible lab water solution that addresses all of these requirements.

Water is a major component of all cell culture media and is, therefore, needed to prepare media, buffers, and additives, as well as to serve many ancillary functions, such as heating, cooling, cleaning and rinsing. Thus, water quality plays an important role in the outcome of cell culture experiments.

HPLC is an analytical procedure for separation, identification and quantification of substances using liquid chromatography. The beginnings of HPLC – High Pressure Liquid Chromatography – go back to the 60’s. Thanks to improved column materials and equipment, it has come to be known as High Performance Liquid Chromatography since the end of the 70’s.

In this Q&A, BioPharm International spoke with Sebastian Weber, product manager for lab weighing at Sartorius, about how to achieve data integrity, minimize risk and the potential for FDA violations, and how digital workflows can be supported by technology like the Cubis II lab balance.

An examination of Novel gene therapy development, understanding the biologic, the materials it contacts and intricacies of equipment, service offerings and partners to ensure effective cold-chain scale-up in cryogenic operations.

Whitepaper on the importance of a robust biopharmaceutical cold chain. Explore the logistical challenges involved in cold chain transport. Read about critical drivers for solution selection by biologic, developmental phase, and operations.

Screening studies of candidate proteins are critical in biopharmaceutical discovery. Preliminary assessment of the quality of the protein solutions by dynamic light scattering is imperative for reliable binding results.

The seasonal influenza vaccine market is projected to reach more than $4 Billion USD by the end of 2022. It is a safe assumption that as demand for seasonal influenza vaccines increases, so too with the demand for contract manufacturing organizations (CMOs) to support.

The Lucullus process information management system facilitates bioprocess development and optimization by centralizing data management and control of multiple BR1000 bioreactor systems that each employ dynamic PAT-driven glucose feeding

In this work we demonstrate the effectiveness of Design of Experiment methodology for upstream process development through the execution of transient gene expression optimization and oxygen mass transfer characterization studies.

This application note describes the drug-to-antibody determination of brentuximab vedotin using a ternary gradient with isopropanol as third channel organic modifier.

Regulatory agencies recommend digital solutions to protect data. Explore the regulatory environment surrounding data integrity and what to look for in a laboratory information management system (LIMS) to ensure compliance.

In this paper, we present an alternative targeted metabolite profiling approach using high resolution accurate mass (HRAM) mass spectrometry with full scan analysis.

Analytical techniques are essential to ensuring the quality, efficacy, and safety of biopharmaceutical products. Advances in instruments and methods are providing biopharmaceutical drug developers, process and manufacturing managers, and quality teams with the capabilities to identify potential problem areas quickly and effectively, and to expedite drug production. In this eBook, the editors share the new technologies and methodologies to analyze and characterize monoclonal antibodies, protein therapeutics, and emerging therapies, as well as best practices to ensure the integrity of analytical test data and evaluate cleaning validation efforts.

Wastewater monitoring has been widely adopted by scientists to effectively detect and monitor infectious pathogens. Methods of detection and surveillance for SARS-CoV-2 are outlined in this paper and can be adapted for other pathogens.

Here, Sartorius provides an overview of cell line development and the associated hurdles. We will then discuss potential solutions that form part of an effective risk-management strategy and improve productivity.