Wyatt Technology

Articles

AAV Application Notebook: characterizing AAVs with light scattering v2

Wyatt’s instruments and techniques constitute platform methods for effective product and process development, as well as quality control, of AAVs for gene therapy.

Identification of Insulin Oligomeric States v2

SEC-MALS identifies monomers, dimers, hexamers and higher aggregates of insulin to determine optimal formulation, storage and administration conditions.

RT-MALS - Real-time product attributes, from lab to plant

Multi-angle light scattering, a powerful technology for biophysical characterization of biologics and LNPs, can also serve as an effective PAT tool to monitor product attributes during DSP.

Understanding Antibody and Viral Glycoprotein Interactions v2

SEC-MALS and CG-MALS characterize viral glycoprotein (vGP) self-association and the absolute stoichiometry and affinity of vGP:antibody interactions.

SEC-MALS and CG-MALS: Complementary Techniques to Characterize Protein-DNA Complexes v2

This white paper presents the characterization of protein-DNA complexes using two complementary multi-angle light scattering techniques, SEC-MALS and CG-MALS.

Solutions for Lipid Nanoparticle Characterization in Product and Process Development v2

Light scattering quantifies key attributes of lipid nanoparticle gene vectors such as payload, size, titer, and stability in formulation and physiological media.

Characterizing lentiviral and gammaretroviral vectors by batch DLS and FFF-MALS

This note demonstrates the use of DLS and online multi-angle light scattering with field-flow fractionation (FFF-MALS) for characterizing retrovial viral vectors.

Influence of heating rates on thermostability characterization by DLS-SLS

Dynamic and static light scattering are applied to show that the choice of heating rate significantly impacts thermostability measurements of an IgG.

SEC-MALS Method for Characterizing mRNA v2

SEC-MALS quantifies biophysical attributes of mRNA including molar mass, percent aggregates, Rg and Rh, and how they are affected by formulation and storage conditions.