Lipid-based nanoparticles (LNPs) are effective non-viral vectors for delivering messenger RNA products (mRNA), most notably used for vaccine production against the recent SARS-CoV-2 pandemic. In this executive summary, you will discover a robust and high-throughput kit-based analysis of nucleic acids extracted from different mRNA-LNP samples.
As more gene therapy applications make inroads into research and clinical practice, the development and safe manufacturing of the therapeutic products involved have demanded more from associated analytical technologies. One of the most widely used gene-therapy vectors is AAV, and key technologies for the characterization of AAVs include CE and LC-MS.
Gene therapy is creating a host of opportunities for the treatment and prevention of diseases, but additional analytical techniques are needed to support the development of promising therapeutics. This ebook on Capillary Electrophoresis Methods for Gene Therapy Analysis explores techniques for protein, vaccine, and gene therapy analyses with an emphasis on CE.
• Background on capillary electrophoresis • Importance of glycan screening • Benefits of high-throughput screening with intuitive data analysis