Whitepapers

To maintain high purity with an untagged protein, consider protein purification workflow development using the Bio Rad NGC Chromatography System, prepacked EconoFit Columns, and Stain Free gel technology. 

Read a case study about resin screening, process development, and scale-up purification of a retrovirus-like particle which was scalable, fast, and low-cost during the clinical-grade manufacture of retrovirus vectors.   

A new approach using the novel, easy-to-connect Thermo Scientific MAbPac RP capillary column for determining glycosylation site occupancy of therapeutic antibodies from the analysis of their tryptic digest.

Harnessing utilization data to drive asset lifecycle decision-making

TOYOPEARL NH2-750F resin is a salt-tolerant AEX resin ideal for the removal of endotoxins in mAb. It works in the presence of 150 mmol/L NaCl and a relatively low pH.

By measuring fundamental biophysical attributes, light scattering aids in vaccine discovery, development, and manufacture. This paper covers light-scattering characterization of vaccine classes spanning a large range of physicochemical properties.

Tumor-infiltrating lymphocytes may hold the key to treating solid tumors with cell therapies, and BioIVT’s DTC product line is a great source for TILs. In this white paper, you’ll read about defining what TILs are, their potential therapeutic applications, the characterization of BioIVT’s current donor pool by TIL content and the frequency of TILs by tumor tissue type.

This article will discuss pharmaceutical package testing specifically Helium leak detection technology and how it solves cold supply chain challenges of today’s high-risk pharmaceutical products.  This article also addresses the importance of phase appropriate leak testing from manufacturing through product lifecycle.

Explore single-use bag system technologies for freeze/thaw applications in bulk drug substance (BDS) manufacturing. Transitioning to SUT can be an efficient, cost-effective option for biopharmaceutical manufacturers to hit performance targets.

Aggregates can affect the efficacy and safety of biologics. Few biophysical tools offer a combination of structural and functional assessment. Octet® systems can detect aggregates while monitoring functional activity at the formulation stage of drug development.

Eurofins’ whitepaper discusses insourcing & outsourcing solutions to solve the bio/pharma industry’s challenges with meeting drug development timelines and budgets with restricted headcounts.

Paper examines how cryogenic cold-temperature solutions are gaining favor versus traditional mechanical refrigeration methods in the manufacturing, storage, and distribution of vaccines due to their enhanced efficacy, stability and yield.

Used by leading pharma companies and CDMOs, the Beacon system offers an integrated end-to-end automated workflow for mammalian cell line development. Clones can be selectively enriched for unique phenotypes and multiple assays can be used to rapidly measure productivity of different antibody molecules.

This document outlines references to 21 CFR Part 11 and EudraLex Annex 11 and how they apply to the implementation of SoftMax Pro GxP Data Acquisition and Analysis Software in regulated environments.

This case study examines the benefits and challenges Nephron Pharmaceuticals Corporation faced integrating a STERIS VHP® Biodecontamination system into their high-volume compounding facility.

Learn about the use of the MAbPac RP capillary column for utmost sensitivity and excellent selectivity for the mass spectrometric analyses of intact proteins and mAb subunits.