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Bringing Scalability to Metabolic Flux Analysis Using Machine Learning to Accelerate LC-MS Interpretation
Metabolic Flux Analysis (MFA) is a powerful technique used to characterize metabolic phenotype driving to improved productivity in biomanufacturing. MFA is most powerful when absolute concentrations of the metabolic intermediates are measured, but doing so in practice is often impractical due to inherent limitations of conventional absolute quantitation by mass spectral analysis. Recently, advances in artificial intelligence (AI) have been applied to solving the problem of broad, untargeted, absolute quantitation in liquid chromatography-mass spectrometry (LC-MS). These new approaches extend readily to the determination of absolute concentrations of stable isotopically-labeled metabolic intermediates, offering a new tool for MFA. Dr Sam Yenne from Metalytics Inc., a company that specializes in the science of metabolic flux, has recently assessed and adopted Pyxis, a new tool for absolute quantitation of raw LC-MS data. Dr Yenne describes MFA, its utility in biopharmaceutical development, associated challenges and how Pyxis impacts those challenges.
NGS-Based Viral Safety Testing for ATMPs: Mandatory or Just an Option?
Characterization and Release Testing for AAV Therapies
Characterization and Release Testing for AAV Therapies – the Importance of Empty/Partial/Full Capsid Analysis and its Impact on Potency
Recap Key Industry Trends for Viral Clearance and NGS
Learn highlights form the 2024 event, including new strategies for viral clearance and NGS applications for viral safety testing.
Manufacturing & Virus Safety Testing of HEK293 Cells for Viral Vector Production
Cell banking and cell line characterization experts are sharing why HEK293 cells are important for viral vector production for CGT products.
Cell banking and cell line characterization integrated solutions
Your biologic can only be as successful as the cells behind them. Learn about our full spectrum of CGMP cell banking and cell line characterization services.