Whitepapers

Cytiva experts answer your top questions about challenging host cell protein assays to improve risk mitigation.

This white paper investigates best practices and tangible benefits associated with a risk-based quality management (RBQM) approach to clinical trial management.

Assessing a drug candidate early in discovery and development minimizes the risk of costly downstream failure. This white paper illustrates the application of automated DLS for aggregation and stability investigations.

This paper details various USP subvisible particulate tests used to assure the minimization of particle counts in intravenous injections and the requirements and technologies used to meet them.

This paper includes a brief introduction to light scattering instruments and techniques, and how they are coupled with fractionation techniques. For several classes of vaccines – including subunit vaccines, mRNA-LNPs, polysaccharide conjugates, and plain old viruses – case studies demonstrate the utility and breadth of analyses using the light scattering toolkit. These include measuring size distributions, characterizing protein-protein binding, and quantifying glycan content in glycoproteins or nucleic acid cargo in nanocarriers. Multiple ways to detect aggregation and other measures of stability are also described.

4D-LC/MS allows characterization of mAbs by cation-exchange chromatography followed by online desalting, denaturation, reduction, tryptic digestion and peptide mapping.

Digital transformation centered on LIMS turns data into the knowledge that improves outcomes. What can you learn from three real-world transformations? Read our white paper.

The proportional–integral–derivative (PID) control mechanism is used for a variety of processes, including dissolved oxygen (DO) control. This protocol introduces a method developed to optimize the PI values on Eppendorf bioprocess controllers.

Combining high performance protein A capturing and a single polishing step on a salt-tolerant anion exchange resin, downstream costs were reduced by 45% in this Tosoh 2-step process for mAb purification.