SCIEX

Articles

Guide Decisions through Drug Development: Localize Critical PTMs at the Sub-Unit Level

Webinar Date/Time: Wed, Jul 24, 2024 12:00 PM EDT

A Deep Dive into the Characterization of a Complex cIEF Electropherogram from an ADC Using a Novel Integrated icIEF-UV/MS System

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Charge heterogeneity is present in most biopharmaceutical protein products. During the manufacturing process, charge heterogeneity of the protein therapeutics can occur due to enzymatic cleavage and chemical post-translational modifications (PTM). For therapeutics like ADCs, not only the antibody contributes to the heterogeneity but also the linker and payload, which add even more complexity to the charge variant profiles. Characterizing the charge heterogeneity of ADCs is essential for critical quality attribute (CQA) assessment to ensure drug safety, efficacy, and potency.

Webcasts

SCIEX

Articles

Guide Decisions through Drug Development: Localize Critical PTMs at the Sub-Unit Level

A Deep Dive into the Characterization of a Complex cIEF Electropherogram from an ADC Using a Novel Integrated icIEF-UV/MS System

What bottleneck? New strategies for a better glycosylation profile

mAb characterization using flash oxidation technology and mass spectrometry

mAb Characterization Process Innovations

Ready for the Real-World: Middle-Down Analysis for Cell Line Optimization

Mass information on charge variants is changing the game

Defining PQAs Linked to Color Change in Biotherapeutics During Process Development

Break Through the Boundaries of Purity Analysis of Long Guiding RNAs for New CRISPR Gene Editing Systems

True High-Throughput Bioanalysis