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Achieve high-resolution nanobody aggregate and fragment characterization with sub-2µm SEC UV and native LC/MS detection, and resolve important post translational modifications with non-denaturing HIC.
Denaturing (reversed-phase) and non-denaturing (size exclusion) analyses of novel siRNA conjugated monoclonal antibodies by LC/MS
How to optimize your ultra-high performance size exclusion separations, using biocompatible UHPLC instrumentation with attention to minimizing extra-column dead volume.
This work highlights a newly-released Agilent workflow for profiling and quantitation of sialic acids in biotherapeutic glycoproteins. This new workflow includes all the reagents necessary for sample preparation of sialic acids and also features a qualitative Sialic Acid Reference Panel ase well as quantitative NANA and NGNA standards.
The benefits of using a charged-surface modified C18 reversed-phase column for improved performance and peak shape of a synthetic peptide using LC/MS methodology.
Transitioning validated methods between instruments is sometimes a challenge. Using a peptide mapping example, we demonstrate exceptional data consistency between the Agilent 1290 Infinity II LC and the biocompatible Agilent 1290 Infinity II Bio LC.
Excellent rentention time and peak area reproducibility are possible even with highly challenging shallow gradients for ion exchange chromatography.
Learn how to increase column lifetime with an improved monolithic affinity chromatography column designed for rapid screening of monoclonal antibody titer in cell culture supernatant.
By removing iron from the LC flow path, the Agilent Infinity II Bio LC is perfectly suited for the high salt concentrations used in HIC-based drug-to-antibody ratio characterization.
Learn about Agilent's Gly-X N-glycan sample preparation platform and available dye options for LC/FLD and LC/MS analysis of N-glycans from biotherapeutic glycoproteins.
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