Manufacturing Equipment, Biologics

A brief case study of a facility-fit analysis provides insight into how to adjust capacity when moving from clinical-to commercial-scale production.

The authors explain why Catalent decided to transition from stainless steel to single-use systems.

Scaling up stem-cell cultures requires careful consideration of the bioreactor design.

This article discusses the evaluation of a novel single-use fluidized bed centrifuge for harvesting of antibodies.

Industry wants more innovation, but can suppliers meet customers' needs?

The authors present a case study identifying a contaminant.

Comparing the economic feasibility of a typical glycosylated protein.

A case study to compare the performances of several types of mixing in disposable bags with stainless steel bioreactors.

Computational fluid dynamics can resolve performance problems.

Computational fluid dynamics is a powerful tool to optimize processes.

An algorithmic approach to fine tune facility design and predict capacity.

How to improve facility design and predict capacity.

In new disposables projects, it is critical that engineering, procurement, and operations groups work together early on to manage supply chain risk.

An analysis of current and upcoming industry challenges.

A discussion of past achievements and future expectations of recombinant protein production yields from mammalian cells.

Process-modeling tools can ensure smooth tech transfer.

The current focus on cost-of-goods (COGS) models is underplaying the benefits of disposables technology in biopharmaceutical manufacturing. The best method for accounting for the benefits of reduced and delayed capital expenditures is through the use of NPV analysis.

Disposable technologies that mimic the conventional stainless-steel bioreactor will be most readily adopted