Manufacturing, Separation and Purification

A Look at the Affinity Chromatography Landscape

January 01, 2019

New ligands are being developed to meet the separation and purification needs of next-gen biologics.

Efficacy of a Simple Static Cleaning Procedure for SPTFF

January 01, 2019

A key technology that can help achieve a continuous production flow is single-pass tangential flow filtration.

Separation and Purification of a Tissue-Type Plasminogen Activator from Trichoderma reesei

December 01, 2018

This research proposes a method for separating and purifying tissue-type plasminogen activator from a fungal cell source.

Tosoh Bioscience Moves to Acquire Semba Biosciences

November 30, 2018

The investment builds on a collaboration the companies entered into in 2007 for various biomanufacturing projects.

Single-Use Mixing Technology for Virus Clearance (Part 2: Compatibility, Leachables, and Scale-Up Studies)

November 01, 2018

The second half of this article describes the testing methods used by the authors to demonstrate the applicability of single-use mixing technology for virus inactivation.

Validating Virus Clearance in a Single-Use System Part 1: Film Adsorption and Virus Inactivation Studies

October 01, 2018

This article explores the use of single-use mixing technology in a detergent-based virus inactivation step during a monoclonal antibody production process.

Improving Aggregate Removal to Enhance Clinical Manufacturing of MAbs

September 28, 2018

Hydrophobic interaction chromatography (HIC) in flow-through mode offers a more efficient and cost-effective polishing/purification process to remove monoclonal antibody aggregates while maintaining purity at ≥99% than a mixed-mode bind/elute procedure.

Assessing Viral Inactivation for Continuous Processing

September 28, 2018

Testing demonstrates an automated semi-continuous process strategy for viral inactivation with steps that mimic batch processing.

3M Enhances Emphaze AEX Hybrid Purifier

September 13, 2018

The new features on the purifier deliver additional sizes and sterilization/sanitization compatibility.

Ensuring Viral Safety of Viral Vaccines and Vectors

September 01, 2018

Viral vaccines and viral vectors used in biotherapeutic applications carry the risk of microbial contamination, which must be addressed.