Upstream Processing

Achieving High Yields in Upstream Processing of Plasmids

Process and plasmid design optimization, disposable equipment, and flexible platform processes all play important roles.

High-titer Vector Producing Cells

Decreasing vein to vein time saves lives.

Weighing the Benefits of Fermentation for New Biotherapies

The industry revisits the pros and cons of microbial fermentation at scale for biotherapeutics.

How Predictive Modeling Can Benefit Bioreactor Performance

September 02, 2022

A predictive modeling approach can offer tighter process control, which can optimize bioreactor output.

Outlining Successful Steps for Scale-Up and BLA Filings

August 02, 2022

Successful scale-up and BLA filings for products manufactured by microbial biomanufacturing require strategic planning.

Plant-based Expression Systems are Gaining Mainstream Advantage

July 02, 2022

Industry adoption of plant-made biologics remains slow, but plant-based technology gains an advantage by mainstream exposure.

Avantor Partners with GeminiBio on Custom Hydrated Solutions and Cell Culture Media

June 29, 2022

Under the collaboration, Avantor and GeminiBio will offer custom cGMP solutions to enhance process efficiency and accelerate speed-to-market of novel emerging therapy modalities.

MilliporeSigma Intensifies Upstream Processing with New BioContinuum Seed Train Platform Offering

June 27, 2022

MilliporeSigma’s new BioContinuum Seed Train Platform offering enables a fully closed bioprocessing environment for both fed-batch and perfusion N-production.

Seqirus Announces Completion of $156 Million Expansion of Vaccine Manufacturing Facility

June 10, 2022

The expansion at Seqirus’ Holly Springs, N.C., manufacturing facility will support the formulation and fill/finish of influenza vaccines.

Considerations for US Fetal Bovine Serum Sourcing

June 02, 2022

Extensive work has greatly expanded the possibilities for fetal bovine serum sourcing.

908 Devices and CPI Partner to Optimize Cell Culture Media for Improved Process Control

May 10, 2022

908 Devices and CPI have formed a collaboration to optimize cell culture media to allow for improved process control.

Addressing the Training Gap for Single-Use Technologies

May 02, 2022

Workforce training is crucial for biopharmaceutical manufacturing.

Large-Scale Single-Use Bioreactors Can Maximize Long-Term Scale Up

April 02, 2022

The growing demand for antibody and other bio-therapeutics will require long-term scale-up solutions.