Upstream Processing

Engineering Approaches to Cell Lines

Bioengineering offers practical tools for host cell evolution.

Cell Culture Processing Continually Advances

Automation and digitalization technologies push cell culture bioprocessing forward.

Data Analytics Helps Upstream Workflows

Modeling techniques help improve upstream bioprocessing workflows.

Sartorius Launches Expansion in South Korea with Mullti-Million Dollar Investment

December 02, 2021

Sartorius will invest approximately €270 million (US$305 million) to expand its biopharmaceutical manufacturing activities in South Korea’s biopharm hub.

Lonza Invests in Microbial Development Lab Expansion

November 18, 2021

Lonza is expanding its microbial development capabilities at its Visp, Switzerland, site to support clinical and commercial drug development programs.

Perfusion Cell Culture is Gaining Ground Upstream

November 02, 2021

The adoption of perfusion cell culture continues to advance with the help of PAT tools.

Large-Scale Single-Use Bioreactors Prove Mettle Amid Growing Demand

October 02, 2021

Large-scale single-use bioreactors prove successful as limits are tested.

Limits and Successes Define Large-Scale SUBs Path

October 01, 2021

SUB bioreactor performance has had seen its limits and successes.

Bioprocessing Innovations Pose New Challenges for Fermentation

September 02, 2021

Advancements in bioprocessing technologies test microbial fermentation adaptability.

Single-Use Technologies Prove Effective for Viral Vector Process Development

August 02, 2021

The benefits of single-use technologies for upstream viral-vector processes clearly outweigh their disadvantages.

Catalent Biologics Launches New Cell Line Expression Technology

July 22, 2021

Catalent Biologics has launched its new cell line expression technology, GPEx Lightning, which aims to shorten drug substance development timelines by up to three months.

Gyros Protein Technologies and Cygnus Technologies to Develop Impurity Reagent Sets

July 09, 2021

The collaboration continues as the companies design bioprocess impurity reagent sets to detect residual HCP from HEK 293 cells.

Cytiva Acquires Intermountain Life Sciences

July 01, 2021

The acquisition of Intermountain Life Sciences will double Cytiva’s capacity for buffers and liquid cell culture media at its manufacturing site in Logan, Utah.