Upstream Processing

Cell-free Expression Systems Offer Alternatives

Cell-free expression shows promise in preclinical applications but presents scale-up challenges.

Recombinant Supplements Offer Lower Contamination Risk

Demand for recombinant microorganism-based cell culture supplements.

Upstream Processing Drives Maximum Output

Biopharma responds to demand dynamics for upstream bioprocessing capacity.

Synthetic Biology Offers a Solution to Cell Therapy Source Material Constraints

October 02, 2020

An innovation such as synthetic biology can develop a consistently stable starting cell line for cell therapy source material.

Current Challenges with Cell Culture Scale-up for Biologics Production

October 02, 2020

Bioreactor technology advances can offer seamless manufacturing scale-up and can reduce the timeline and cost of biologics production.

Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines

September 03, 2020

This article will explore the traditional path from the laboratory to the clinic and how the fixed-bed technology provides an alternative solution to meet commercial demands.

Using Process Modeling to Troubleshoot a Bioprocess

August 02, 2020

Process modeling offers an opportunity to troubleshoot for and anticipate difficult aspects of a bioprocess.

Improving mAb Manufacturing Productivity by Optimizing Buffer and Media Prep Process Flow

July 02, 2020

Innovative approaches, including ready-to-use materials and in-line dilution, can significantly streamline overall bioprocessing operations.

Plasma-Based Antibody Therapies Battle Against COVID-19

June 01, 2020

Therapies for early and late treatment and passive immunization of COVID-19 are needed and can be developed using antibodies from recovered patients.

Biopharmaceutical Manufacturing and the Power of Synthetic Biology

May 01, 2020

Synthetic biology has advanced the scope and scale with which biologically derived therapeutics can be developed.

Bioreactors Redefine Upstream Productivity

April 03, 2020

New bioreactor designs, coupled with better media, process intensification and analytics, continue to improve upstream bioprocessing.

Sartorius Launches New Automated Single-Use Bioproduction Platform

March 09, 2020

The new BIOSTAT STR Generation 3 with BIOBRAIN bioproduction platform offers process intensification with automated feed and bleed and integrated cell retention functionality.

Improving Upstream Predictability

March 02, 2020

Better understanding and control of cell behavior is yielding benefits, upstream and beyond.