Non-infectious mock virus particles that mimic the physicochemical properties of live infectious viruses can be used as spiking agents during viral clearance testing. Review results from several studies using an economical spiking surrogate—a non-infectious minute virus of mice-mock virus particle (MVM-MVP)—to demonstrate viral clearance in industrial processes. Tuesday, Oct 6, 2020 at 11am EDT| 8am PDT| 4pm BST| 5pm CEST On demand available after final airing until Oct. 6, 2021.
As viruses can arise during the manufacture of biopharmaceuticals, regulatory agencies require viral clearance validation studies for each biopharmaceutical prior to approval. These studies are typically conducted in biosafety level (BSL)-2 facilities and require large capital and human resources. Due to these hurdles, process knowledge pertaining to viral clearance is limited during development and characterization.
This webcast will explore the use of a BSL-1 compatible, non-infectious minute virus of mice (MVM) particle to predict viral clearance results over a wide variety of process development applications.
The use of an accurate, economical and quantifiable non-infectious viral surrogate enables downstream purification scientists to study viral clearance throughout process development.
In this webcast, learn about the results from several studies using an economical spiking surrogate, a non-infectious MVM-mock virus particle (MVM-MVP). Results from an anion exchange design-of-experiment study, ion exchange high-throughput screening, and downstream purification of an adeno-associated virus (AAV)-based viral vector will be presented.
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Speaker: David Cetlin, MS, Senior Director Research and Development, Cygnus Technologies, LLC.
Time and Date: Tuesday, Oct 6, 2020 at 11am EDT| 8am PDT| 4pm BST| 5pm CEST
On demand available after final airing until Oct. 6, 2021.
Sponsor: Cygnus Technologies