Economic Modeling of Multi-Column Chromatography

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Webinar Date/Time: Tuesday, December 12, 2023 Session 1: 9:00 am EDT | 1:00pm GMT | 2:00pm CET Session 2: 1:00 pm EDT| 12:00pm CDT| 10:00am PDT

Learn how fast you can come out ahead on Multi-Column Chromatography CapEx

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Event Overview:

Multi-column chromatography (MCC) can be used to intensify Protein A chromatography in a continuous mode, increasing productivity threefold or more. While many of the benefits of MCC (reduction of materials, decreased suite time, and higher resin utilization) have been identified, a detailed analysis would be helpful to organizations considering whether to invest time and CapEx money in transitioning to MCC and debating what MCC format is most advantageous for them. Tosoh Bioscience modeled these scenarios with BioSolve modeling software to generate a detailed comparison of the processing times, materials costs, and non-material costs for purification platforms at different titers, with both prepacked and self-packed columns.

Key Learning Objectives:

  • Learn how titer, CIP time, and prepacked columns impact the overall cost of goods
  • How clinical vs commercial settings impact the cost of the Protein A step
  • How much money can MCC really save compared to batch

Who Should Attend:

Downstream Process Development Scientists, MSAT Engineers, Bioprocess Engineers


Jennifer Knister
Product Specialist, Multi-Column Chromatography Systems
Tosoh Bioscience

Jennifer Knister is a bioprocess engineer with over 6 years of experience in the downstream process development of mAbs, antibody fragments, and other proteins. Jennifer completed her undergraduate degree and Masters of Science Engineering in Biomedical Engineering at the University of Michigan. She joined Tosoh Bioscience as a Product Specialist for the Octave Multi-Column Chromatography product line. Her work revolves around helping customers develop a deep understanding and transition to Multi-Column Chromatography and continuous manufacturing.

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