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  • 9:00 am EDT | 1:00pm GMT | 2:00pm CET
  • 1:00 pm EDT| 12:00pm CDT| 10am PDT
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Economic Modeling of Multi-Column Chromatography

Tuesday, December 12, 2023

Session 1: 9:00 am EDT | 1:00pm GMT | 2:00pm CET
Session 2: 1:00 pm EDT| 12:00pm CDT| 10:00am PDT
Event Overview:

Multi-column chromatography (MCC) can be used to intensify Protein A chromatography in a continuous mode, increasing productivity threefold or more. While many of the benefits of MCC (reduction of materials, decreased suite time, and higher resin utilization) have been identified, a detailed analysis would be helpful to organizations considering whether to invest time and CapEx money in transitioning to MCC and debating what MCC format is most advantageous for them. Tosoh Bioscience modeled these scenarios with BioSolve modeling software to generate a detailed comparison of the processing times, materials costs, and non-material costs for purification platforms at different titers, with both prepacked and self-packed columns.

Key Learning Objectives:
  • Learn how titer, CIP time, and prepacked columns impact the overall cost of goods
  • How clinical vs commercial settings impact the cost of the Protein A step
  • How much money can MCC really save compared to batch
Who Should Attend:


Downstream Process Development Scientists, MSAT Engineers, Bioprocess Engineers




Featured Speakers


Jennifer Knister
Jennifer Knister
Product Specialist, Multi-Column Chromatography Systems
Tosoh Bioscience


Jennifer Knister is a bioprocess engineer with over 6 years of experience in the downstream process development of mAbs, antibody fragments, and other proteins. Jennifer completed her undergraduate degree and Masters of Science Engineering in Biomedical Engineering at the University of Michigan. She joined Tosoh Bioscience as a Product Specialist for the Octave Multi-Column Chromatography product line. Her work revolves around helping customers develop a deep understanding and transition to Multi-Column Chromatography and continuous manufacturing.

Speaker's LinkedIn: Jennifer Knister



For any technical questions please email Jorge de la Bandera: jdelabandera@mjhlifesciences.com