Acoustic Separator Streamlines Clarifications

The Cadence Acoustic Separator (CAS) from Pall Life Sciences enables the purification of bioprocesses fluids without the use of primary depth filters or centrifuges. CAS was developed by FloDesign Sonics and is licensed by Pall. CAS’s acoustic wave separation (AWS) technology applies acoustic forces across a countercurrent flow of bioprocess fluid to generate three-dimensional standing waves that trap cells in their nodes. The cells in the bioprocess fluid will agglomerate and eventually sediment as it loses its buoyancy. 

The CAS does not cause any significant increase in temperature or damage to cells or proteins. The CAS system allows for the reduction of 75% of the filtration area and associated buffer volume requirements. AWS technology is applicable for the clarification of biologic products, including recombinant therapeutic proteins and monoclonal antibodies. In addition, the CAS is a single-use clarification system that enables continuous processing.

Pall Life Sciences