Manufacturing Equipment, Upstream Processing

Late-stage and commercial biomanufacturing pose a challenge to cell-culture processing.

Silicone is one of the polymeric materials that can be used for single-use components and assemblies in biopharmaceutical manufacturing.

Understanding differences in bioreactor lifecycle, design space, and product platforms is important for selecting a bioreactor type.

Parker Bioscience will expand laboratory, cleanroom, office, and warehouse facilities at its Birtley, UK manufacturing site.

More published data and initial regulatory approvals are needed to drive adoption of continuous bio-manufacturing.

The new platform is expected to speed up cell line development.

Fujifilm acquires cell culture media companies Irvine Scientific Sales Company and IS Japan.

Developments and investments in single-use systems advance upstream biomanufacturing.

Sartorius Stedim Biotech has launched a new automated parallel bioreactor system for perfusion culture.

The contract development and manufacturing organization has expanded biologics capacity at its facility in Berkeley, CA.

Recent investments show expansion activity in cell culture facilities.

MilliporeSigma will collaborate with IPS and G-CON to offer end-to-end, turnkey, modular MAb manufacturing.

BioTek Instruments has released a second edition of its BioSpa software that now offers users a simplified but effective interface for kinetic imaging or detection workflows.

A quality-by-design approach that implements PAT offers advantages in upstream cell-culture processing.

The company’s new modules offer scalable single-pass diafiltration and were exclusively showcased during its Leadership Forum series in Westborough, MA.

The success of a truly integrated continuous processing platform relies on the collaborative efforts of upstream and downstream specialists.

This article summarizes the approaches, challenges, and future perspectives for the characterization of N-glycans in biopharmaceutical products.

Improving the bioreactor growth environment increases the rigor of bioprocessing runs.

Pump systems must be designed to meet the needs of specific processes, including preventing cross-contamination and damage due to shear forces.

BioPharm International spoke with Trevor Marshall, director of enterprise systems integration at Zenith Technologies about automating processes in upstream processing.

BioPharm International spoke with Selexis CEO and Chairman Igor Fisch, PhD about the latest cell-line development advances.

The authors outline cell-line development and process scale-up for an antibody program in which the antibody requires additional processing by a site-specific enzyme for correct functionality.

Advances in cell culture media technology have helped achieve safer biologics.

The platform combines an expression system with equipment and process controls to enable rapid development and scale-up of robust titers.

The company announced the launch of its first-in-class Lynx CDR connectors at INTERPHEX 2016.

A modular cell-culture platform demonstrates accelerated process development.

This article presents first-hand perspectives from industry users to suppliers of single-use sensors.

EMD Millipore will provide process development services for Precision Biologics’ preclinical monoclonal antibody.

They may not be glamorous, but buffers play an important role in biopharma manufacturing.

The use of commercially available media to achieve high titer in early process development is discussed.