Small molecules to complex biologics: Mastering bioanalytical workflows using high resolution mass spectrometry (HRMS)

From small organic acids to complex ADCs: See how high‑resolution mass spectrometry enables flexible, sensitive bioanalytical workflows, through real‑world case studies.

Register Free: https://www.biopharminternational.com/bp_w/HRMS

Event Overview:

Modern therapeutics require analytical platforms that deliver sensitivity and flexibility, accommodating a wide range of molecular structures. The webinar will encompass case studies on the targeted quantitation of highly hydrophilic small organic acids and the in vivo characterization of antibody drug conjugates (ADCs) using a high resolution mass spectrometer, the ZenoTOF 7600+ system. Here, small polar molecules like succinic acid were applied for the demonstration of targeted quantitation, while trastuzumab MMAE was used for the in vivo drug-to-antibody ratio (DAR) study.

Key Learning Objectives

• Learn how HRMS can be applied for modern bioanalytical challenges, from small molecules to biologics in complex matrices
• Discover methods to alleviate the sensitivity bottleneck for small polar molecules as well as low abundance biologics
• Demonstration of robust quantitative and qualitative workflows on an HRMS system, highlighting a single platform solution

Who Should Attend

• Lab Director, Lab Manager, Sr Scientist, Staff Scientist
• Scientists

Speakers:

Andrew Pinkham
Principal Scientist II
Meadowhawk Biolabs

Andrew joined Meadowhawk biolabs in November of 2022 as a Principal Scientist II. He obtained a PhD in chemistry from Ohio State University with a heavy emphasis on bioinorganic chemistry. Andrew has been working in regulated and non-regulated bioanalytical LC-MS for 8 years with a focus on large molecule quantification.

Ryan Fantasia
Senior Scientist, LCMS Discovery Bioanalysis
Meadowhawk Biolabs

Ryan joined Meadowhawk Biolabs in January of 2023 as a Senior Scientist. He received his degree in Marine Science from Rutgers University - New Brunswick, where he focused on biochemistry and molecular biology applications in environmental science. Ryan has 9 years of experience working in bioanalysis at various contract research organizations, most recently focused on bioanalysis of proteins and Antibody Drug Conjugates by LC-MS.

Register Free: https://www.biopharminternational.com/bp_w/(U)HPLC