New data show risk-based and centralized monitoring shifts effort across roles, sites, and timelines, reshaping how sponsors plan CRA capacity needs.
News|Articles|March 3, 2026
Executive Summary: Therapeutic Nucleic Acids: Advanced Solutions for Downstream Processing and Analysis
Author(s)Tosoh Bioscience
Advanced chromatographic and analytical approaches can help overcome the complex downstream purification challenges of therapeutic nucleic acids; these innovations include on-column DMT cleavage and real-time anion-exchange chromatography coupled with multi-angle light scattering (AEX MALS) integration. By exploring next-generation resin technologies and sustainable, solvent-free workflows, this article highlights how process scientists can enhance purity, yield, and scalability for complex drug manufacturing.
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