Temperature and Relative Humidity Control to Reduce Bioburden in a Closed Cell Processing and Production System without Disinfectants

Yan He

Yan He is the senior scientist at BioSpherix, Ltd., 25 union St. Parish, NY

,
Shannon Darou

Shannon Darou is a technician at BioSpherix, Ltd., 25 union St. Parish, NY

,
Stassa P.D. Henn

Stassa P.D. Henn is an intern at BioSpherix, Ltd., 25 union St. Parish, NY

,
Rose Walter

Rose Walter is an intern at BioSpherix, Ltd., 25 union St. Parish, NY

,
Tony Cundell

,
Randy Yerden

Randy Yerden is the chief executive officer at BioSpherix, Ltd., 25 union St. Parish, NY

,
Alicia D. Henn

Alicia D. Henn is the chief scientific officer, all at BioSpherix, Ltd., 25 union St. Parish, NY

BioPharm International, BioPharm International-06-01-2021, Volume 34, Issue 6
Pages: 36–41

Controlling certain atmospheric conditions in a closed NGI processing chamber can reduce bioburden without disinfectants.

Chemical disinfectants pose risks to live cells. In a closed cell handling system, temperature and relative humidity (RH) were examined as a means to control microbes. Compared with biological safety cabinet conditions, lower RH and physiologic temperatures increased log reductions on polypropylene and steel surfaces. Environmental control can reduce the need for disinfectants.

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Peer-Reviewed

Submitted: December 2, 2020
Accepted: February 5, 2021

About the authors

Yan He is the senior scientist; Shannon Darou is a technician; Stassa P.D. Henn is an intern; Rose Walter is an intern; Randy Yerden is the chief executive officer; and Alicia D. Henn*, ahenn@biospherix.com, is the chief scientific officer, all at BioSpherix, Ltd., 25 union St. Parish, NY; and Tony Cundell is a consultant of BioSpherix, Ltd., and located at Microbiological Consulting, LLC, Scarsdale, NY.

Article Details

BioPharm International
Vol. 34, No. 6
June 2021
Pages: 36–41

Citation

When referring to this article, please cite it as Y. He et al., “Temperature and Relative Humidity Control to Reduce Bioburden in a Closed Cell Processing and Production System without Disinfectants,” BioPharm International 34 (6) 2021.

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