No control over the Freezing?

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Freezing & thawing in static and blast freezers is uncontrollable. It takes a long time and leads to reduced product quality due to the effects of cryoconcentration. Plate-based freezers give you back full control over the freezing rate - whatever is best for your product. Be One Step Ahead and cool down with best freezing results.

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The One Process Solution for Bulk Drug Substances

Advanced Fluid & Cold Chain Management for large volumes of drug substances, including robust protection for single-use bags, automated aseptic aliquoting, controlled plate-based freezing & thawing, ultra-cold storage and smart cold chain shipping.

Watch video: The One Process Solution for Bulk Drug Substances - YouTube


"Bestcellers“: Controlled Filling & Freezing of Cells

What is needed are modular and controllable technologies that support biopharmaceutical companies to cope with process versatility. The adaptability of process solutions to different requirements and scenarios while complying with current good manufacturing practices (cGMP) will meet the needs of biomanufacturing companies along the journey from drug development to commercialization. In the end, state-of-the-art filling and freezing technologies significantly improve cell viability.

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“How controlled freezing becomes a reality”

Controlling the freezing behavior of drug substance is the ultimate goal in pharmaceutical manufacturing. It opens doors to process reproducibility, consistent quality of the final drug product by maintaining uniform conditions for the biopharmaceuticals during freezing and consequently for frozen storage and shipment. In a comprehensive study the impact of ice front growth speed on scalability of freezing protein solutions has been evaluated throughout different scales, by reaching high product homogeneity during freezing and by maintaining highest protein activity.

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