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Recombinant mAbs tend to be unstable and susceptible to modification/degradation. These mAbs need to be identified/monitored for successful drug development. New advanced LC–MS workflows have been developed to meet such needs.

AAE and MS integration enables comprehensive HCP analysis, facilitates process development, and helps determine whether your HCP ELISA is fit for purpose of process monitoring and product lot release.

HCPs can threaten drug product efficacy and stability. LC–MS/MS using automated sample prep can address HCP analysis challenges. Software and hardware workflow upgrades can optimize HCP analysis methods.

This paper summarizes approaches for modulating antibody effector functions and pharmacokinetics, and provides examples of antibodies in clinical studies employing such approaches.

Combining high performance protein A capturing and a single polishing step on a salt-tolerant anion exchange resin, downstream costs were reduced by 45% in this Tosoh 2-step process for mAb purification.

This application note demonstrates the importance of using orthogonal mass spectrometry techniques for primary sequence identification of monoclonal antibodies.

Growing trends in oligonucleotide and gene therapy development Commentary on the current global and regional market landscapes The latest methods for the advancement of oligonucleotide and gene therapies and much more!

Preventing contamination in pipetting is paramount to achieving reliable results. It requires identification of the potential contamination mechanisms in order that they can all be addressed.

Multiple separation steps are often required to eliminate product- and process-related impurities impacting biopharmaceuticals. This study shows that buffer composition has an effect on target purity and recovery when using Nuvia aPrime 4A, a mixed-mode resin.