Simplifying Seed Train: A Benchtop System for Intensified Inoculation of Large-Scale Bioreactors

Intensify the inoculation of large-scale bioreactors with a new seed train benchtop module. Discover a CDMO’s experience using the module for low-risk and cost-effective viral production.

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Event Overview:

The use of adherent-cell cultures for commercial manufacture of advanced therapies requires inoculating large-scale bioreactors with vast amounts of cells. Traditional cell-expansion systems such as plastic flatware are still used for this purpose, but are generally associated with significant aseptic risk, footprint, and production costs. Univercells Technologies has designed a novel benchtop solution to tackle these challenges, delivering reliable, automated, and intensified seed train. Discover how a CDMO has used this new technology, achieving harvest cell densities above 2x109 cells/m² with >90% cell detachment in a small-footprint, low-risk, and cost-effective seed train process.

Key Learning Objectives:

• Challenges of generating seed train for large-scale manufacture of advanced therapy medicinal products with adherent cells.
• The concept of bioreactor-to-bioreactor seed train, and the possibility of detaching over 90% of cells immobilized in a fixed-bed bioreactor through mechanical and enzymatic action.
• How a new benchtop module enables intensified and reliable seed train generation for industrial bioreactors, providing drastic footprint and cost savings compared to traditional technologies.

Speakers:

Clément Dumont
Product Manager
Univercells Technology

Clément Dumont, product manager at Univercells Technologies, focuses on the expansion of the scale-X portfolio with intensified bioreactor systems and innovative process analytical technologies. He has experience in the areas of bioprocess development, characterization, and optimization, which he currently applies to the development of the scale-X cell collect module for seed train generation. Clément also has product management experience in the field of medical devices and holds a master’s degree in biomedical engineering from the UCLouvain, Belgium. 

Cédric Meeüs
Bioprocess Engineer
Exothera

During his studies (Master’s Degree in Industrial Engineering in Pharmaceutical Biotechnology), Cédric Meeüs joined Univercells to support his thesis regarding the validation and design of the soon-to-be scale-X™ carbo. He then remained in the company and joined its process development team, taking charge of upstream bioprocessing and validating the scale-X carbo and nitro bioreactor systems. Cédric has since joined Exothera and has gathered a wide knowledge of scale-X technology. He also specializes in the areas of gene therapy, viral vectors, recombinant proteins, and the adaptation of suspension cells to fixed-bed bioreactors.

Register Free: https://globalmeet.webcasts.com/starthere.jsp?ei=1588661&tp_key=a5faada3f1