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Feature|Videos|July 18, 2024

Navigating Challenges and Embracing Opportunities to Optimize mRNA Therapies

Author(s)Chris Spivey, Peter Marks, MD, PhD, Fouad Atouf, PhD

The discussion covers the challenges of optimizing mRNA therapies, including the diverse behaviors of mRNA in biological systems, as well as the opportunities presented by emerging mRNA technologies like circular and self-amplifying RNAs, and the role of regulators in ensuring quality control of these novel products.

Episodes in this series

EP. 1 The Benefits of Working with mRNA for Therapeutics

EP. 1 The Benefits of Working with mRNA for Therapeutics

EP. 2 Public Perception and Communicating the Potential and Safety of mRNA

EP. 2 Public Perception and Communicating the Potential and Safety of mRNA

EP. 3 Lessons from Vaccine Development and Future Possibilities

EP. 3 Lessons from Vaccine Development and Future Possibilities

EP. 4 Streamlining Rare Disease Drug Development

EP. 4 Streamlining Rare Disease Drug Development

EP. 5 Navigating Challenges and Embracing Opportunities to Optimize mRNA Therapies

EP. 5 Navigating Challenges and Embracing Opportunities to Optimize mRNA Therapies

EP. 6 Overcoming Delivery Challenges of mRNA Therapeutics

EP. 6 Overcoming Delivery Challenges of mRNA Therapeutics

EP. 7 The Future of Manufacturing, Safety, and Collaboration

EP. 7 The Future of Manufacturing, Safety, and Collaboration

EP. 8 Key Takeaways from the Peer Exchange Discussion “Aligning mRNA Progress with Regulatory Streamlining”

EP. 8 Key Takeaways from the Peer Exchange Discussion “Aligning mRNA Progress with Regulatory Streamlining”

The expert panel discussed the diversity of mRNA structures and behaviors, as well as the challenges and opportunities in optimizing mRNA design and synthesis. New directions in mRNA structure and chemistry, such as circular RNAs and self-amplifying RNAs, were also discussed, as well as the increasing complexity of mRNA therapeutics from a regulatory perspective.

Discussion Topics

00:07 - Challenges and opportunities in optimizing mRNA therapies
01:44 - Emerging mRNA technologies
04:20 - Role of regulators

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