Cation Exchange Resin Achieves Higher Dynamic Binding Capacity

Tosoh Bioscience, a provider of chromatographic resins for the purification of biopharmaceutical drugs in commercial manufacturing processes, introduced TOYOPEARL Sulfate-650F, a strong cation exchange resin that exhibits a high salt tolerance, for sale in the Americas. TOYOPEARL Sulfate-650F resin allows for lowered operating costs by offering higher dynamic binding capacities for IgG. This resin can achieve a dynamic binding capacity of >120 g/L of monoclonal antibody (mAb) and exhibits pressure-flow properties at 30 cm inner diameter of up to 500 cm/hr (0.2 MPa). The resin is ideal for applications performed in physiological conditions or for post-protein A removal of aggregates. According to the company, the chromatographic resin captures mAb aggregates over a wide pH range without losing its binding capacity for mAb, resulting in higher resolution between monomer and aggregates.