Drug Digest: Engineering LNPs Beyond the Liver for Genetic Medicines

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Osamu Shirokizawa

Osamu Shirokizawa is president of Life Scientia.

Articles by Osamu Shirokizawa

Nikolai Sorokin/Stock.adobe.com - concept illustrating a needle that can cause pinholes

Proposing a New Method of Detecting Pinholes in Single-Use

ByToshihiko Otsubo,Shinji Tsuji,Yoshiaki Miko,Tetsuya Moritake,Osamu Shirokizawa,Takashi Kaminagayoshi

September 1st 2020

The increased use of single-use bags in biologic manufacturing poses the risk of pinholes and other defects that cannot currently be tested for.

Development of a Technique for Quantifying Protein Degradation

ByXi (Dylan) Wang,Takashi Kaminagayoshi,Tomohiro Doi,Kosuke Takenaka,Yoshiaki Miko,Osamu Shirokizawa,Andrew Walsh

November 1st 2017

This article demonstrates that a modified SDS–PAGE can be easily used as a tool for quantifying the degree of protein degradation.

Latest Updated Articles

Proposing a New Method of Detecting Pinholes in Single-Use
September 1st 2020
Development of a Technique for Quantifying Protein Degradation
November 1st 2017