Downstream Processing
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Fouling Mechanisms of Filters in the Harvest Development of Monoclonal Antibody Therapeutics—Pt 2
The authors evaluated the potential of direct filtration for multiple biopharmaceutical candidates. This article is Part 2 of the study.
Fouling Mechanisms of Filters in the Harvest Development of Monoclonal Antibody Therapeutics—Pt 1
The authors present a methodology to assess the contribution of individual filters to overall capacity of the direct filtration train, and elucidate how capacity is affected by characteristics of the cell culture broth and process parameters.
Stepping Up Process Control with Single-Use Systems
SUS aids biopharma manufacturers to overcome the rigidity of more traditional stainless-steel technologies.
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Performance advantages are driving adoption of membrane chromatography for advanced therapy purification.
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The inaugural BioPharma By the Numbers provides a data-driven look at how automation in bioprocessing is driving efficiency, reducing errors, and addressing capacity challenges.
Solutions are emerging to manage advanced modalities and evolving regulatory requirements for viral clearance.
Increasing efficiency and quality through effective application of advanced technologies is becoming predominant.
The Purolite AP+50 affinity chromatography resin has a 50-micron bead size that offers dynamic binding capacity of the AP resin platform while providing durability for monoclonal antibody capture.
A continuous biomanufacturing platform can process higher/lower quantities of a drug as needed and allow manufacturers to respond to changing markets.
Although automation is increasingly adopted in biomanufacturing, challenges remain in implementing it at the cell harvesting step.
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Webinar Date/Time: Tue, May 20, 2025 2:00 PM EDT
The benefits include reduced contamination risks, simplified validation processes, and streamlined operations.
Many factors must be considered to overcome the challenges associated with viral clearance.
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Webinar Date/Time: Thu, Dec 12, 2024 11:00 AM EST
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Webinar Date/Time: Tue, Oct 8, 2024 11:00 AM EDT
Collaboration between technology providers and biopharma manufacturers are enabling both evolutionary and novel developments.
Downstream processes may be streamlined by using automation.
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