
Pfenex Partners with Hospira to Develop Lucentis Biosimilar
Pfenex announced that it entered into an agreement to partner with Hospira on the development and commercialization of PF582, a biosimilar candidate to Lucentis.
On Feb. 10, 2015, Pfenex, a clinical-stage biotechnology company, announced that it would partner with Hospira to develop and commercialize worldwide sales of PF582. The injectable drug, which is currently in Phase Ib/IIa clinical trials, is a biosimilar candidate to Genentech’s Lucentis (ranibizumab injection).
As part of the agreement, Pfenex will receive an upfront payment of $51 million and an addition $291 million based on milestones set by the companies. The Phase III clinical trial costs will be split between the two companies, however Hospira will be responsible for manufacturing and commercializing the product worldwide. The Phase Ib/IIa trials are being conducted among 24 randomized patients who receive monthly intra-ocular injections of PF582 or Lucentis for three doses, with an ongoing patient evaluation for 12 months. The trials were designed to measure safety and tolerability, with other objectives including pharmacokinetic and pharmacodynamic evaluations to demonstrate its biosimilarity to Lucentis.
This announcement comes only four days after
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