Myriad Genetics Expands Companion Diagnostic Pact with AstraZeneca

September 9, 2013
BioPharm International Editors

Myriad Genetics and AstraZeneca expand their companion diagnostic pact for AztraZeneca?s investigational drug candidate olaparib.

Myriad Genetics, a molecular diagnostics company, has expanded its agreement with AstraZeneca to provide companion diagnostics for olaparib, an anticancer drug candidate. Olaparib is an investigational orally active poly-ADP ribose polymerase (PARP) inhibitor being developed by AstraZeneca treating various tumor types including BRCA-mutated breast and ovarian cancers. BRCA 1 or BRCA 2 gene mutations are responsible for the majority of hereditary breast and ovarian cancers, according to information from Myriad Genetics.

Under the expanded agreement, Myriad will build out a new laboratory within its Salt Lake City, Utah regulations for companion diagnostic devices. In August 2013, FDA approved an investigational device exemption filed by Myriad, for BRCA analysis, a propretiary gentic test by Myriad for identifying patients with BRCA 1 or BRCA 2 gene mutations to enable clinical studies with olaparib to include BRACAnalysis testing as a diagnostic.

The collaboration builds on an existing agreement through which Myriad provided supply of BRACAnalysis to support the Phase II development program for olaparib in breast and ovarian cancers.

Source: Myriad Genetics

Related Content:

News | Biopharma News