MorphoSys and Galapagos to Co-develop Novel Therapeutic Antibodies in Bone and Joint Disease

MorphoSys AG (Munich, Germany) and Galapagos NV (Mechelen, Bengium) have launched a long-term co-development alliance aimed at discovering and developing antibody therapies based on novel modes of action in bone and joint disease, including rheumatoid arthritis, osteoporosis, and osteoarthritis.

The alliance spans all activities from target discovery through completion of proof of concept clinical trials of novel therapeutic antibodies. Both companies will contribute their core technologies and expertise to the alliance. Galapagos will provide antibody targets implicated in bone and joint disease in addition to its adenoviral target discovery platform to discover additional targets for antibody development. MorphoSys will contribute its HuCAL antibody technologies to generate fully human antibodies directed against these targets. The initial goal is to further validate the targets through disease-specific in vitro and in vivo testing of the antibodies. After successful validation, the alliance will select antibody programs for preclinical and clinical development. Following proof of concept in human clinical trials, programs will be partnered for subsequent development, approval, and marketing.

Under the terms of the agreement, Galapagos and MorphoSys will share the research and development costs and all future revenues equally. Decisions will be made by a joint steering committee comprising members of both companies. An initial set of three targets implicated in bone and joint disease has been selected for the collaboration, and Galapagos is already commencing with production of these proteins for the alliance. Generation of antibodies directed against these targets will start in 2009. If successful, the first antibody programs based on these novel targets could enter the clinic within four to five years.