Lonza to Manufacture TxCell Product
TxCell announces manufacturing agreement with Lonza for its HLA-A2 CAR-Treg cellular product.
TxCell SA announced on May 31, 2018 that Lonza Pharma & Biotech will manufacture TxCell’s HLA-A2 CAR-Treg cellular product (TX200), which is in development for the prevention of chronic rejection after organ transplantation.
TxCell finalized its CAR-Treg manufacturing process, and the transfer to Lonza started in February 2018, according to Lonza’s timeline. The companies report the transfer will be complete and clinical manufacturing is expected to start by the first quarter of 2019. Accordingly, TxCell now expects to file its first CTA with TX200 in the first part of 2019.
Lonza will manufacture clinical batches of TxCell’s HLA-A2 CAR-Treg cellular product from its production site in Geleen, The Netherlands, and the final product can be shipped in a frozen state to clinical sites in Europe and the United States. TxCell has demonstrated that the drug product could be both frozen and thawed with no change in cellular phenotype and function, the companies report in the press statement.
Source: Lonza Pharma & Biotech
Ushering in Industry 4.0 with the IDMO Model to Solve the CGT Manufacturing Bottleneck
May 28th 2025Global scale-up requires developing replicable processes that work the same no matter where they are performed. This can be accomplished with smart factories that utilize fully automated manufacturing platforms.
Novel Modalities Spur Shift in Outsourcing Processes and Partnerships
May 8th 2025While a one-stop shop still has its advantages, sponsor companies and CDMOs are starting to see each other not as transactional relationships, but true partners with a common goal of getting drugs to patients faster.
New Cancer Research and Treatment Center in Development in London
May 1st 2025Aviva Capital Partners and developer Socius are investing £1 billion in a 12-acre site to be located at the London Cancer Hub next to The Institute of Cancer Research, London and The Royal Marsden NHS Foundation Trust’s Sutton site.
