From Aggregation to Impurity Profiling: Analytical Best Practices for GLP-1RAs

Explore advanced analytical strategies for characterizing critical quality attributes (CQAs) in GLP-1 receptor agonists using SEC-MALS and RPC-MS. This session provides practical guidance and best practices with Waters’ end-to-end LC, column, detector, and compliant-ready software solutions.

Register Free: https://www.biopharminternational.com/bp_w/impurity-profiling

Event Overview:

As GLP-1 receptor agonists (GLP-1RAs) continue to transform the treatment landscape for diabetes and weight management, ensuring the integrity and quality of these complex molecules is more critical than ever. This webinar explores advanced analytical strategies for characterizing critical quality attributes (CQAs), with a focus on size-exclusion chromatography with multi-angle light scattering (SEC-MALS) and reversed-phase chromatography with mass spectrometry (RPC-MS).

Attendees will gain insights into SEC column selection for impurity profiling, the use of SEC for oligomer identification and aggregation analysis, and the comparative strengths of MALS and MS detection. The session also features a side-by-side analysis of liraglutide and semaglutide, demonstrating how integrated data workflows using Empower CDS for MALS analysis streamline complex analyses while supporting compliance requirements and product quality—an essential in GxP environments.

With built-in tools for method standardization, secure data handling, and audit-trail integrity, Empower CDS helps laboratories meet regulatory expectations while improving efficiency. Whether you’re developing or monitoring GLP-1RAs, this session offers practical guidance and best practices using Waters’ end-to-end LC, column, detector, and software solutions.

Key Learning Objectives:

• Understand critical quality attributes (CQAs) for GLP-1 receptor agonists
• Explore column selection strategies for SEC and RPC
• Compare MALS and MS detection techniques for aggregation and purity analysis
• Learn how Empower CDS supports compliance-ready, unified data workflows
• Learn advanced methods for HCP antibody coverage analysis, HCP identification, and quantification in drug substance samples

Speakers:

Bill Warren, MS
Principal Product Manager
Waters Corporation

Bill Warren, MS, is principal product marketing manager within Waters Consumables and Automation Group. Over his 39-year tenure at Waters, he has developed various biomolecule applications and has helped manage a comprehensive line of bioseparation consumables for DNA/RNA, amino acid, peptide, protein, and glycan applications. His current focus is on chemistry consumables for proteins, DNA/RNA, and cell therapy-related applications.

Neil J. Lander, BS
Principal Product Manager
Waters Corporation

Neil J. Lander, BS, has worked for Waters Corporation since 1994 and serves as a principal product manager in the Informatics group. Lander provides support for Empower CDS software and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives. Prior to joining Waters Corporation, he was an analytical chemist, gaining experience in the cosmetics and specialty chemical industries.

Register Free: https://www.biopharminternational.com/bp_w/impurity-profiling