Feature|Events|October 30, 2026

Refining Biomarker-Based Patient Selection for ADC Trials

Author(s)Bea Mann
Fact checked by: Sydnee Thompson

ADC trials are moving from binary antigen testing to quantitative, multiparameter biomarker models that better predict efficacy and toxicity.

The expansion of antibody-drug conjugates (ADCs) into earlier lines of therapy and across diverse tumor types hinges on improved patient selection during clinical development. Developers can refine patient selection with biomarker-based enrollment strategies that move beyond binary classification of antigen expression and incorporate multiparameter response prediction.

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