	Novimmune SA and Baxalta announced on Sept. 2, 2015 that the companies plan to partner on the research of novel humanized bispecific antibodies through the exploitation of Novimmune’s kappa-lambda bispecific antibody technology platform.

	According to Novimmune CEO Jack Barbut, bispecific antibodies currently used in biopharmaceutical applications have been constructed using chemical linkers, non-human material, antibody fragments, or forced engineering-and Novimmune's platform is unique in that it would allow antibodies to assemble naturally, he said in a press release. Natural assembly, rather than the use of foreign sequences, could lead to enhanced product stability, better product half-life, and could also be associated with lower immunogenicity risk, noted the release.

	Once developed, the final product would be an unmodified fully human bispecific immunoglobulin G (IgG). Novimmune says it has mechanisms in place for the expression of kappa-lambda-bodies in mammalian cells, and also has a purification platform that is “easily scalable and transferrable,” according to the company’s 

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The collaborative effort will be focused on fully humanized antibodies.