
- BioPharm International-03-01-2015
- Volume 28
- Issue 3
3M Purification’s Emphaze AEX Hybrid Purifier
The all-synthetic clarifying product line contains both an anion-exchange nonwoven media and a fine-particle, bioburden reduction membrane.
3M Purification’s Emphaze A
EX Hybrid Purifier combines three 3M core technologies-advanced polymer materials, fine fiber nonwovens, and porous membranes-into a novel purification media. The all-synthetic clarifying product line contains both an anion-exchange nonwoven media and a fine-particle, bioburden reduction membrane.
The product is a combination of two types of media (Q-functional nonwoven and membrane) that work synergistically together to provide product purity after clarification when using a single-unit operation. The nonwoven hydrogel together with the qualifying membrane remove insoluble particles well below 0.1 µm in size to reduce turbidity. The chromatographic capacity of the Q-functional nonwoven reduces negatively charged, soluble impurities including DNA and host cell protein. The hybrid purifier can be used in monoclonal antibody purification before the protein A affinity column, which results in greater purity downstream of the protein A operation.
Articles in this issue
over 10 years ago
USP Publishes Monoclonal Antibody Guidelinesover 10 years ago
Maintaining the Stability of Biologicsover 10 years ago
Springing Forwardover 10 years ago
Reinventing the Cold Chain in a High-Stakes Marketover 10 years ago
A Robust CAPA System for a Global Supply Chainover 10 years ago
CMOs Plan for Capacity Expansionsover 10 years ago
Vaccine Development and Production Challenges Manufacturersover 10 years ago
Detecting Protein Aggregates and Evaluating their Immunogenicityover 10 years ago
Re-use of Protein A Resin: Fouling and Economicsover 10 years ago
SEC in the Modern Downstream Purification ProcessNewsletter
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